| 李道娟,梁 迪,师 金,等.2009—2020年河北省肿瘤登记地区宫颈癌发病特征趋势分析[J].中国肿瘤,2026,35(5):371-376. |
| 2009—2020年河北省肿瘤登记地区宫颈癌发病特征趋势分析 |
| Trends of Cervical Cancer Incidence Characteristics in Cancer Registration Areas of Hebei Province from 2009 to 2020 |
| 投稿时间：2026-01-30 |
| DOI：10.11735/j.issn.1004-0242.2026.05.A005 |
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| 中文关键词: 宫颈癌 发病 组织学类型 分期 河北 |
| 英文关键词:cervical cancer incidence histological subtype stage Hebei |
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| 中文摘要: |
| 摘 要：［目的］ 分析2009—2020年河北省肿瘤登记地区宫颈癌发病率、组织学类型及临床分期的变化趋势。［方法］ 收集河北省38个肿瘤登记处2009—2020年上报的全部宫颈癌新发病例数据，对数据进行合并汇总后，分别计算不同地区、年龄组的宫颈癌粗发病率与标准化发病率；采用Joinpoint回归模型计算平均年度变化百分比（average annual percentage change，AAPC），分析发病率长期变化趋势；并系统解析河北省肿瘤登记地区宫颈癌的组织学类型及临床分期分布特征。［结果］ 2009—2020年河北省肿瘤登记地区宫颈癌粗发病率为12.98/10万，整体呈显著下降趋势，粗发病率从2009年的14.51/10万降至2020年的11.93/10万，AAPC为-2.42%；中国人口标化发病率（age-standardized incidence rate by Chinese standard population，ASIRC）、世界人口标化发病率（age-standardized incidence rate by world standard population，ASIRW）同步呈显著下降趋势，AAPC分别为-3.55%、-3.74%。2009—2020年河北省城市地区宫颈癌粗发病率为12.53/10万，略低于农村地区的13.26/10万；农村地区ASIRC呈显著下降趋势，城市地区ASIRC下降趋势无统计学意义。宫颈癌新发病例数与发病率均在50~54岁年龄组达到峰值，45岁以后农村地区发病率显著高于城市地区。有明确组织学类型的病例中，鳞状细胞癌为最主要的组织学类型，其次为腺癌；2009—2020年鳞状细胞癌占比呈逐年下降趋势，腺癌及其他组织学类型占比呈上升趋势。宫颈癌临床TNM分期中，Ⅰ期占比最高，为49.68%，占比随分期升高呈递减趋势，Ⅳ期占比最低，为5.38%。［结论］ 2009—2020年河北省肿瘤登记地区宫颈癌的发病率呈下降趋势，需重点关注50~54岁农村女性高危人群，提升筛查率与早诊早治水平，降低晚期宫颈癌确诊比例。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the trends of cervical cancer incidence in terms of incidence period， histological subtype and clinical stage in cancer registration areas of Hebei Province from 2009 to 2020. ［Methods］ Data of all new cervical cancer cases reported by 38 population-based cancer registries in Hebei Province from 2009 to 2020 were collected and pooled. The crude and age-standardized incidence rates of cervical cancer in different regions and age groups were calculated respectively. The Joinpoint regression model was used to calculate the average annual percentage change (AAPC) to analyze the long-term trend of incidence. Meanwhile， the distribution characteristics of histological subtype and clinical stage of cervical cancer in the study areas were systematically analyzed. ［Results］ From 2009 to 2020， the crude incidence rate of cervical cancer in the cancer registration areas of Hebei Province was 12.98/105， showing a significant downward trend overall. The crude incidence rate decreased from 14.51/105 in 2009 to 11.93/105 in 2020， with an AAPC of -2.42%. The age-standardized incidence rate by Chinese standard population(ASIRC) and the age-standardized incidence rate by world standard population (ASIRW) also presented significant synchronous downward trends， with AAPCs of -3.55% and -3.74%， respectively. The crude incidence rate in urban areas was 12.53/105， slightly lower than 13.26/105 in rural areas from 2009 to 2020 in the cancer registration areas of Hebei Province. The ASIRC in rural areas showed a significant and continuous decline， while the downward trend in urban areas was not statistically significant. Both the the number of new cases and incidence rate of cervical cancer peaked in the age group of 50~54 years old， and the incidence rate in rural areas was significantly higher than that in urban areas after the age of 45 years old. Among cervical cancer cases with clear anatomical subsite information， endocervical cancer accounted for more than 50%， and exocervical cancer accounted for more than 35%. Among cases with definite histological type， squamous cell carcinoma was the predominant histological type， followed by adenocarcinoma. From 2009 to 2020， the proportion of squamous cell carcinoma showed a year-by-year downward trend， while the proportions of adenocarcinoma and other histological types showed an upward trend. Regarding the clinical TNM staging of cervical cancer， stage Ⅰaccounted for the highest proportion (49.68%)， which decreased gradually with the advance of stage， and stage Ⅳ accounted for the lowest proportion (5.38%). ［Conclusion］ The incidence of cervical cancer in the cancer registration areas of Hebei Province from 2009 to 2020 shows a downward trend. It is necessary to focus on the high-risk population of rural women aged 50~54 years old， improve the screening rate and the level of early diagnosis and treatment， and reduce the proportion of confirmed advanced cervical cancer cases. |
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