| 戴 霖,王 彪,张念杰,等.环境内分泌干扰物对结直肠癌发生及进展的影响及其潜在调控机制研究进展[J].中国肿瘤,2026,35(2):152-162. |
| 环境内分泌干扰物对结直肠癌发生及进展的影响及其潜在调控机制研究进展 |
| Advances on the Effects of Environmental Endocrine Disrupting Chemicals on the Carcinogenesis and Progression of Colorectal Cancer and Their Potential Regulatory Mechanisms |
| 投稿时间：2025-01-10 |
| DOI：10.11735/j.issn.1004-0242.2026.02.A010 |
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| 中文关键词: 环境内分泌干扰物 结直肠癌 作用机制 环境暴露 |
| 英文关键词:environmental endocrine disrupting chemicals colorectal cancer mechanism of action environmental exposure |
| 基金项目:国家自然科学基金（82460525） |
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| 中文摘要: |
| 摘 要：结直肠癌（colorectal cancer，CRC）是常见的胃肠道恶性肿瘤之一，其发生及进展与遗传、环境和饮食结构改变等因素密切相关，其中环境因素占据重要位置。随着工业化和城市化的不断推进，环境内分泌干扰物（environmental endocrine disrupting chemicals，EDCs） 已严重影响公共卫生安全。研究发现，EDCs可通过饮水、食物等途径进入人体，并可多种途径驱动CRC的发生及进展：①破坏肠道黏膜屏障、诱发肠道菌群失调；②影响炎症因子的表达及异常释放；③诱导氧化应激；④激活PI3K/AKT、Wnt/β-catenin等信号通路，促进细胞增殖-凋亡失衡及上皮-间质转化（epithelial-mesenchymal transition，EMT）进程。全文就EDCs的来源和种类、对CRC的影响和可能调控机制、在CRC风险评估、预后中的潜在价值进行综述，旨在为研究CRC的潜在环境暴露危险因素提供依据，并为CRC的预防和治疗提供新思路。 |
| 英文摘要: |
| Abstract： Colorectal cancer(CRC) is one of the common gastrointestinal malignancies， and its carcinogenesis and progression are closely related to genetic， environmental， and dietary factors， with environmental factors playing a significant role. With the continuous advancement of industria-lization and urbanization， environmental endocrine disrupting chemicals (EDCs) have seriously affected public health. Studies have found that EDCs can enter the human body through drinking water， food， and other sources， and can drive CRC development in a variety of ways： ①disrupting the intestinal mucosal barrier and inducing gut microbiota dysbiosis； ②disrupting the expression and release of inflammatory factors； ③inducing oxidative stress； ④activating PI3K/AKT， Wnt/β-catenin and other signaling pathways to cause an imbalance between cell proliferation and apoptosis and promote the epithelial-mesenchymal transition (EMT) process. Studies have shown that EDCs are associated with the risk and progression of CRC. This paper reviews the origin and types of EDCs， their effects on CRC and possible regulatory mechanisms， and their potential value in CRC risk assessment， prognosis， in order to provide a basis for studying potential environmental risk factors for CRC and new ideas for the prevention and treatment of CRC. |
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