| 王 红,陈 琼,徐慧芳,等.2021年河南省肿瘤登记地区女性乳腺癌流行特征及2010—2021年变化趋势分析[J].中国肿瘤,2026,35(2):137-143. |
| 2021年河南省肿瘤登记地区女性乳腺癌流行特征及2010—2021年变化趋势分析 |
| Incidence and Mortality of Female Breast Cancer in Henan Cancer Registration Areas in 2021 and Their Trends from 2010 to 2021 |
| 投稿时间：2025-09-26 |
| DOI：10.11735/j.issn.1004-0242.2026.02.A008 |
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| 中文关键词: 女性 乳腺癌 发病 死亡 趋势分析 河南 |
| 英文关键词:female breast cancer incidence mortality trend analysis Henan |
| 基金项目:河南省科技攻关项目（232102310242） |
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| 中文摘要: |
| 摘 要：［目的］ 分析 2021年河南省肿瘤登记地区女性乳腺癌发病与死亡情况及 2010—2021年发病与死亡变化趋势。［方法］ 收集整理2021年河南省55个肿瘤登记处上报且质控合格的女性乳腺癌发病与死亡资料，分城乡、年龄别计算其发病/死亡粗率、中标率、世标率、构成比、0~74 岁累积率。采用Joinpoint 5.4.0 软件计算 2010—2021年河南省肿瘤登记地区女性乳腺癌中标发病率和死亡率的年度变化百分比（annual percentage change，APC）和平均年度变化百分比（average annual percentage change，AAPC）及其95%置信区间（confidence interval，CI）。［结果］ 2021年河南省肿瘤登记地区女性乳腺癌发病粗率为49.22/10万，中标率和世标率分别为38.52/10万和35.48/10万。乳腺癌死亡粗率为11.29/10万，中标率和世标率分别为7.38/10万和7.20/10万。城市地区女性乳腺癌发病率和死亡率均高于农村地区。女性乳腺癌年龄别发病率在50~54岁组达到高峰，年龄别死亡率在85岁及以上组达到高峰。2010—2021年间，河南省肿瘤登记地区女性乳腺癌中标发病率呈上升趋势（AAPC=1.97%，95%CI：0.86%~3.21%，P<0.05），中标死亡率呈下降趋势（AAPC=-3.16%，95%CI：-5.19%~-1.11%，P<0.05）。［结论］ 河南省肿瘤登记地区女性乳腺癌呈现发病率上升、死亡率下降的趋势，城乡差异仍存在，提示防控重点应由单纯降低死亡转向减轻整体疾病负担，并进一步优化分层管理策略。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the incidence and mortality of female breast cancer in the cancer registration areas of Henan Province in 2021 and to examine their trends from 2010 to 2021. ［Methods］ Data on female breast cancer incidence and mortality in 2021 were collected from 55 qualified cancer registries in Henan Province. Crude rates， age-standardized rates by Chinese (ASRC) and world (ASRW) standard population， proportions， and cumulative rates (0~74 years old) were calculated by urban/rural area and age group. Joinpoint regression (Joinpoint 5.4.0) was used to estimate the annual percentage change (APC) and average annual percentage change (AAPC) for age-standardized incidence and mortality rates from 2010 to 2021. ［Results］ In 2021， the crude incidence rate of female breast cancer was 49.22/105， with ASRC and ASRW of 38.52/105 and 35.48/105， respectively. The crude mortality rate was 11.29/105， with corresponding ASRC and ASRW of 7.38/105 and 7.20/105. Both incidence and mortality rates were higher in urban than those in rural areas. Age-specific incidence peaked in the age group of 50~54 years old， while mortality peaked among women aged ≥85 years old. From 2010 to 2021， the age-standardized incidence rate showed a significant upward trend (AAPC=1.97%， 95%CI： 0.86%~3.21%， P<0.05)， whereas the age-standardized mortality rate declined significantly(AAPC=-3.16%， 95%CI： -5.19%~-1.11%， P<0.05). ［Conclusion］ In Henan cancer registration areas， female breast cancer is characterized by rising incidence and falling mortality， with persistent urban-rural disparities. These findings suggest a need to shift prevention and control focus from merely reducing mortality to mitigating the overall disease burden and refining stratified management strategies. |
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