| 王宏宗,胡军国,刘玉琴,等.2020年甘肃省肿瘤登记地区结直肠癌流行特征及2010—2020年变化趋势分析[J].中国肿瘤,2026,35(2):127-136. |
| 2020年甘肃省肿瘤登记地区结直肠癌流行特征及2010—2020年变化趋势分析 |
| Incidence and Mortality of Colorectal Cancer in Gansu Cancer Registration Areas in 2020 and Trends from 2010 to 2020 |
| 投稿时间：2025-03-28 |
| DOI：10.11735/j.issn.1004-0242.2026.02.A007 |
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| 中文关键词: 结直肠癌 肿瘤登记 发病率 死亡率 趋势变化 甘肃 |
| 英文关键词:colorectal cancer cancer registration incidence rate mortality rate trend analysis Gansu |
| 基金项目:甘肃省自然科学基金（23JRRH0008） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2020年甘肃省肿瘤登记地区结直肠癌发病与死亡情况及2010—2020年发病率及死亡率变化趋势。［方法］ 整理甘肃省肿瘤登记地区上报的2020年结直肠癌数据，计算粗发病率和死亡率、中标发病率和死亡率、世标发病率和死亡率、0~74岁累积发病率和死亡率等指标。利用Joinpoint模型计算平均年度变化百分比（average annual percentage change，AAPC）与年度变化百分比（annual percentage change，APC）及其95%置信区间（confidence interval，CI），分析2010—2020年间结直肠癌发病率与死亡率的变化趋势。［结果］ 2020年甘肃省肿瘤登记地区结直肠癌粗发病率为23.18/10万，中标发病率为14.41/10万，世标发病率为15.89/10万，累积发病率（0~74岁）为1.70%，在全部恶性肿瘤发病中占比为8.91%。结直肠癌粗死亡率为9.08/10万，中标死亡率为5.43/10万，世标死亡率为6.23/10万，累积死亡率（0~74 岁）为0.60%，在全部恶性肿瘤死亡中占比为6.67%。结直肠癌发病率和死亡率均随年龄增长而上升，且均在80~84岁年龄组达到峰值。在地区分布中，皋兰县结直肠癌发病率最高，张家川县死亡率最高，山丹县发病率与死亡率均最低。2010—2020年甘肃省肿瘤登记地区结直肠癌中标发病率整体呈现平稳的态势，而中标死亡率呈现下降趋势（AAPC=-5.17%，95%CI：-9.83%~-0.26%，P<0.05）。［结论］ 2020年甘肃省肿瘤登记地区结直肠癌发病率及死亡率均略低于国内多数地区，2010—2020年间结直肠癌发病率呈现平稳态势，而死亡率呈下降趋势，持续做好早诊早治筛查工作与宣传，是实现发病率与死亡率双下降的重要举措。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and mortality of colorectal cancer in the cancer registration areas of Gansu Province in 2020 and trends from 2010 to 2020. ［Methods］ Data on colorectal cancer reported from cancer registration areas in Gansu Province in 2020 were collected. The crude incidence/mortality rate， age-standardized incidence/mortality rate by Chinese and world standard population (ASIRC/ASMRC， ASIRW/ASMRW)， cumulative incidence/mortality rate (0~74 years old) were calculated. The Joinpoint regression model was used to calculate the average annual percentage change (AAPC)， annual percentage change (APC) and 95% confidence interval (CI)，to analyze trends from 2010 to 2020. ［Results］ In 2020， the crude incidence rate of colorectal cancer was 23.18/105， with ASIRC of 14.41/105， ASIRW of 15.89/105， and cumulative incidence rate (0~74 years old) of 1.70%， accounting for 8.91% of all malignant tumors. The crude mortality rate was 9.08/105， with ASMRC of 5.43/105， ASMRW of 6.23/105， and cumulative mortality rate (0~74 years old) of 0.60%， accounting for 6.67% of all cancer deaths. The incidence and mortality rates of colorectal cancer both increased with age and peaked in the age group of 80~84 years old. Gaolan County had the highest incidence， Zhangjiachuan County had the highest mortality， and Shandan County had the lowest incidence and mortality in the province. From 2010 to 2020， the ASIRC remained stable (AAPC=-0.49%， 95%CI： -2.15%~1.20%， P>0.05)， while the ASMRC showed a significant downward trend (AAPC=-5.17%， 95%CI： -9.83%~-0.26%， P<0.05). ［Conclusion］ In 2020， the incidence and mortality of colorectal cancer in Gansu cancer registration areas were lower than those in most parts of China. From 2010 to 2020， the incidence remained stable， while mortality decreased significantly. Continuous efforts in early diagnosis， treatment， and public health education are crucial to further reduce the incidence and mortality of colorectal cancer. |
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