| 刘 威,司 瑜,张志钢.肿瘤相关中性粒细胞在肿瘤免疫微环境中的作用及治疗研究进展[J].中国肿瘤,2026,35(1):69-80. |
| 肿瘤相关中性粒细胞在肿瘤免疫微环境中的作用及治疗研究进展 |
| Research Progress on the Role and Treatment of Neutrophils in Tumor Immune Microenvironment |
| 投稿时间：2025-05-28 |
| DOI：10.11735/j.issn.1004-0242.2026.01.A010 |
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| 中文关键词: 肿瘤免疫微环境 免疫细胞调控 肿瘤相关中性粒细胞 |
| 英文关键词:tumor immune microenvironment immune cell regulation tumor-associated neutrophil |
| 基金项目:国家自然科学基金（82173154，82471155）；中山大学临床医学研究5010计划（2024004） |
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| 中文摘要: |
| 摘 要：肿瘤免疫微环境（tumor immune microenvironment，TIME）的异质性及免疫细胞空间分布特征，是决定肿瘤进展轨迹与治疗响应的核心因素。全文综述了 TIME 的三大分类模式及其与免疫治疗敏感性的内在关联机制，深入解析了肿瘤相关中性粒细胞（tumor-associated neutrophils，TAN）从早期通过细胞毒性作用、免疫激活及抗原呈递发挥抗肿瘤效应，到后期通过介导慢性炎症、促进基质重塑及诱导免疫抑制推动肿瘤进展的功能动态演变规律，系统阐述了靶向 TAN 的核心治疗策略（阻断中性粒细胞募集与浸润、调节中性粒细胞表型与功能、构建中性粒细胞介导的创新药物递送系统、靶向髓系免疫检查点及探索中性粒细胞靶向-免疫-化疗联合方案），并提出未来需依托单细胞测序等技术解析中性粒细胞异质性，通过时空特异性调控策略精准干预其功能状态、协同现有治疗手段构建高效低毒肿瘤治疗体系的研究方向，旨在为改善肿瘤患者预后提供新方向。 |
| 英文摘要: |
| Abstract： The heterogeneity of the tumor immune microenvironment (TIME) and the spatial distribution cha-racteristics of immune cells are core factors that determine the trajectory of tumor progression and therapeutic response. This paper comprehensively summarizes the three major classification patterns of TIME and their intrinsic association mechanisms with immunotherapeutic sensitivity， deeply analyzes the dynamic functional evolution of tumor-associated neutrophils (TAN)—from exerting antitumor effects in the early stage through cytotoxicity， immune activation， and antigen presentation to promoting tumor progression in the late stage by mediating chronic inflammation， facilitating stromal remodeling， and inducing immune suppression—syste-matically elaborates on the core therapeutic strategies targeting TAN (blocking neutrophil recruitment and infiltration， regulating neutrophil phenotype and function， constructing innovative neutrophil-mediated drug delivery systems， targeting myeloid immune checkpoints， and exploring neutrophil-targeted， immune and chemotherapy combination regimens)， and proposes future research directions， which include analyzing neutrophil heterogeneity using technologies such as single-cell sequencing， precisely intervening in their functional states through spatiotemporally specific regulatory strategies， and constructing a highly effective and low-toxicity tumor treatment system with existing therapeutic approaches， aiming to provide a new direction for improving the prognosis of tumor patients. |
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