| 宋嘉宇,李晏宁,刘丽娜,等.微量元素与头颈部肿瘤的因果关联研究：一项两样本双向孟德尔随机化分析[J].中国肿瘤,2025,34(11):898-910. |
| 微量元素与头颈部肿瘤的因果关联研究：一项两样本双向孟德尔随机化分析 |
| Investigating Causal Relationships Between Serum Trace Elements and Head and Neck Cancers： a Two-Sample Bidirectional Mendelian Randomization Study |
| 投稿时间：2025-06-19 |
| DOI：10.11735/j.issn.1004-0242.2025.11.A009 |
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| 中文关键词: 微量元素 口腔癌 喉癌 口咽癌 甲状腺癌 孟德尔随机化 |
| 英文关键词:trace elements oral cavity cancer laryngeal cancer oropharyngeal cancer thyroid cancer Mendelian randomization |
| 基金项目:国家自然科学基金（82060556）；贵州省科技厅计划基金（黔科合基础-ZK[2024]一般189）；贵州省卫生健康委科学技术基金（gzwkj2025-017） |
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| 摘要点击次数: 88 |
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| 中文摘要: |
| 摘 要：［目的］ 阐明血清微量元素（钙、铜、铁、镁和锌）水平与头颈部肿瘤（口腔癌、口咽癌、喉癌和甲状腺癌）之间的潜在因果关系。［方法］ 首先从全基因组关联研究中获得与钙、铜、铁、镁、锌、口腔癌、口咽癌、喉癌和甲状腺癌相关的单核苷酸多态性（single nucleotide polymorphism，SNP）。采用逆方差加权法（inverse variance weighting，IVW）进行两样本双向孟德尔随机化（Mendelian randomization，MR）分析，因果关系指标采用比值比（odds ratio，OR）及其95%置信区间（confidence interval，CI）。MR-PRESSO和MR-Egger回归检验多效性，“leave-one-out”法进行敏感性分析。［结果］ IVW分析显示，血清镁水平与口腔癌发病之间存在因果关联（OR=0.976，95%CI：0.956~0.997，P=0.025），甲状腺癌与血清钙水平之间亦存在因果关联（OR=1.008，95%CI：1.001~1.015，P=0.023）。此外，未发现其他微量元素与头颈部肿瘤之间的因果关联（P均>0.05）。［结论］ 血清镁水平是口腔癌的保护因素，而甲状腺癌会导致血清钙水平升高。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the potential causal relationships between serum levels of trace elements and head and neck cancers. ［Methods］ Single nucleotide polymorphism (SNP) of oral cancer， oropharyngeal cancer， laryngeal cancer and thyroid cancer， associated with calcium， copper， iron， magnesium， zinc， were obtained from genome-wide association studies (GWAS). A two-sample bidirectional Mendelian randomization(MR) analysis was performed using the inverse variance weighting (IVW) method by calculating odds ratio(OR) and 95% confidence interval (CI). Pleiotropy was assessed using MR-PRESSO and MR-Egger regression， and sensitivity analysis was conducted via the “leave-one-out” method. ［Results］ IVW analysis revealed a causal association between serum magnesium levels and the incidence of oral cancer (OR=0.976， 95%CI： 0.956~0.997， P=0.025)，also between thyroid cancer and serum calcium levels (OR=1.008， 95%CI： 1.001~1.015， P=0.023). No significant causal associations were observed between other trace elements and head and neck cancers (all P>0.05). ［Conclusion］ This MR study suggests that serum magnesium levels serve as a protective factor against oral cancer， while thyroid cancer leads to elevated serum calcium levels. |
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