| 苏 蕾,刘晨野,严鑫鑫,等.慢性乙型肝炎患者肝癌风险预测模型的研究进展与方法比较[J].中国肿瘤,2025,34(11):891-897. |
| 慢性乙型肝炎患者肝癌风险预测模型的研究进展与方法比较 |
| Research Progress and Prospect of Risk Prediction Models for Hepatocellular Carcinoma Related to Chronic Hepatitis B |
| 投稿时间:2025-08-08 |
| DOI:10.11735/j.issn.1004-0242.2025.11.A008 |
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| 中文关键词: 肝细胞癌 乙型肝炎 预测模型 人工智能 生物标志物 |
| 英文关键词:hepatocellular carcinoma hepatitis B prediction model artificial intelligence biomarkers |
| 基金项目:2022年度中国医学科学院肿瘤医院-深圳医院合作基金(CFA202202003);深圳市经济学会科研基金(2024107);深圳市科技计划项目(〔2021〕287号) |
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| 中文摘要: |
| 摘 要:慢性乙型肝炎(chronic hepatitis B,CHB)是肝细胞癌(hepatocellular carcinoma,HCC)的主要病因,对 CHB 患者进行早期 HCC 风险预测与诊断可进一步降低 HCC 发病风险并改善患者预后。国内外学者已提出诸多 CHB 患者 HCC 风险预测模型,在抗病毒治疗时代,此类模型得到新的发展与优化。由于研究背景存在差异,这些模型在抗病毒药物使用情况、纳入变量(如宿主因子、病毒活性、肝硬化状态等)及应用场景上有所不同。同时,人工智能与液体活检技术在风险预测模型中的应用成为新的研究亮点。全文旨在比较迄今为止已报道的 CHB 患者 HCC 风险预测模型,明确各模型特点,探讨适宜的 HCC 风险预测方法,为乙型肝炎病毒相关 HCC 的风险预测提供参考。 |
| 英文摘要: |
| Abstract: Chronic hepatitis B (CHB) is the main cause of hepatocellular carcinoma (HCC). Early prediction and diagnosis of HCC in CHB patients can further reduce the onset risk of HCC and improve patient prognosis. Scholars at home and abroad have proposed a number of HCC risk prediction models for CHB patients, and these models have achieved new development and optimization in the era of antiviral therapy. Due to differences in research backgrounds, these models vary in the use of antiviral drugs, included variables (such as host factors, viral activity, cirrhosis status, etc.) and application scenarios. At the same time, the application of artificial intelligence and liquid biopsy technology in risk prediction models has become a new research highlight. This paper aims to compare the HCC risk prediction models reported so far for CHB patients, clarify the characteristics of each model, explore appropriate HCC risk prediction methods, and provide reference for the risk prediction of hepatitis B virus related HCC. |
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