| 李 灿,邹艳花,肖海帆,等.2021年湖南省肿瘤登记地区口腔和咽喉癌流行特征及2012—2021年变化趋势分析[J].中国肿瘤,2025,34(11):854-861. |
| 2021年湖南省肿瘤登记地区口腔和咽喉癌流行特征及2012—2021年变化趋势分析 |
| Epidemiological Characteristics of Oral and Pharyngeal Cancer in Hunan Cancer Registration Areas in 2021 and Trends from 2012 to 2021 |
| 投稿时间：2025-07-10 |
| DOI：10.11735/j.issn.1004-0242.2025.11.A004 |
|
 |
| 中文关键词: 口腔和咽喉癌 发病率 死亡率 变化趋势 湖南 |
| 英文关键词:oral and pharyngeal cancer incidence mortality change trend Hunan |
| 基金项目:湖南省自然科学基金（2023JJ40408）；湖南省卫生健康高层次人才重大科研专项（R2023117）；湖南省科技创新计划项目（2023ZJ1120）；长沙市自然科学基金（kq2403127） |
|
| 摘要点击次数: 82 |
| 全文下载次数: 5 |
| 中文摘要: |
| 摘 要：［目的］ 分析2021年湖南省肿瘤登记地区口腔和咽喉癌发病与死亡情况及2012—2021年趋势变化。［方法］ 收集湖南省78个质控合格肿瘤登记处2012—2021年口腔和咽喉癌发病与死亡数据，人口数据来源于公安部门户籍人口统计。计算2021年口腔和咽喉癌的发病和死亡粗率、中国人口标化率（中标率）、世界人口标化率（世标率）等指标，中标率和世标率分别采用2000年全国普查标准人口年龄构成和Segi世界标准人口年龄构成为标准进行计算。采用Joinpoint Regression Program 4.9.0.0软件拟合对数线性回归模型，计算2012—2021年口腔和咽喉癌中标发病率、中标死亡率的平均年度变化百分比（average annual percentage change，AAPC），分析其变化趋势。 ［结果］ 2021年湖南省肿瘤登记地区口腔和咽喉癌粗发病率为9.28/10万（男性为15.14/10万，女性为3.07/10万），中标发病率为 6.10/10万；粗死亡率为3.75/10万（男性为6.19/10万，女性为1.16/10万），中标死亡率为 2.16/10 万，男性发病、死亡率均显著高于女性。年龄分布显示，口腔和咽喉癌发病率自30岁后随年龄增长而升高，于60~64岁年龄组达峰值（22.29/10万）；死亡率在35岁后持续攀升，85岁及以上人群达峰值（14.52/10万）。2012—2021年趋势分析表明，口腔和咽喉癌粗发病率和中标发病率分别由2012年的3.50/10万和2.63/10万上升至2021年的9.28/10万和6.10/10万，AAPC分别为12.33%和10.80%；粗死亡率和中标死亡率也均呈现上升趋势（AAPC分别为9.87%、7.21%），趋势变化均具有统计学意义（P均<0.05）。性别分层显示，男性口腔和咽喉癌中标发病率和死亡率AAPC均高于女性（发病率AAPC：男性12.65% vs 女性4.28%；死亡率AAPC：男性8.79% vs 女性4.13%）。年龄趋势分析发现，44岁以下人群中标发病率呈上升趋势（AAPC=11.73%，P<0.001），其中男性AAPC达14.57%；45~64岁、65岁及以上人群中标发病率AAPC分别为11.03%、9.74%，中标死亡率AAPC分别为10.05%、8.19%，趋势变化均有统计学意义（P均<0.05）；44岁以下人群中标死亡率变化无统计学意义（AAPC=5.66%，P=0.087）。［结论］ 湖南省肿瘤登记地区口腔和咽喉癌发病率和死亡率居高不下且呈上升趋势，并存在年轻化倾向，男性及中老年人群为防控重点。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and mortality of oral and pharyngeal cancer in cancer registration areas of Hunan Province in 2021 and the trend changes from 2012 to 2021. ［Methods］ Data on oral and pharyngeal cancer incidence and mortality from 2012 to 2021 were collected from 78 quality-controlled cancer registries in Hunan Province， with population data sourced from household registration statistics provided by public security authorities. Indicators such as crude incidence and mortality rates， age-standardized incidence and mortality rates by Chinese standard population (ASIRC/ASMRC)， and world standard population (ASIRW， ASMRW) in 2021 were calculated. The Chinese standard population (2000 national census) and Segi’s world standard population were used for standardization. Joinpoint Regression Program 4.9.0.0 software was used to fit a Log-linear regression model， and the average annual percentage change (AAPC) of ASIRC/ASMRC of oral and pharyngeal cancer from 2012 to 2021 was calculated to analyze the changing trends. ［Results］ In 2021， the crude incidence rate of oral and pharyngeal cancer in cancer registration areas of Hunan Province was 9.28/105(15.14/105 for males and 3.07/105 for females)， with an ASIRC of 6.10/105； the crude mortality rate was 3.75/105(6.19/105 for males and 1.16/105 for females)， with an ASMRC of 2.16/105. Both the incidence and mortality rates in male were significantly higher than those in female. Age distribution analysis showed that the incidence rate of oral and pharyngeal cancer increased with age after 30 years old， peaking in the age group of 60~64 years old (22.29/105)； the mortality rate continued to rise after 35 years old， reaching the peak in the population aged ≥85 years old (14.52/105). Trend analysis from 2012 to 2021 indicated that the crude incidence rate and ASIRC of oral and pharyngeal cancer increased from 3.50/105 and 2.63/105 in 2012 to 9.28/105 and 6.10/105 in 2021， with AAPC of 12.33% and 10.80%， respectively； the crude mortality rate and ASMRC also showed upward trends (AAPC of 9.87% and 7.21%， respectively)； all trend changes were statistically significant (all P<0.05). Sex stratification revealed that the AAPC of ASIRC and ASMRC of oral and pharyngeal cancer in male were higher than those in female (AAPC of ASIRC： 12.65% for males vs 4.28% for females； AAPC of ASMRC： 8.79% for males vs 4.13% for females). Age-specific trend analysis found that the ASIRC of oral and pharyngeal cancer in the population aged ≤44 years old showed an upward trend(AAPC=11.73%， P<0.001)， with the AAPC of male in this group reaching 14.57%； the AAPC of ASIRC for the age groups of 45~64 years old and ≥65 years old were 11.03% and 9.74%， respectively， and the AAPC of ASMRC for these two groups were 10.05% and 8.19%， respectively， with all trend changes being statistically significant (all P<0.05)； there was no statistically significant change in the ASMRC of the population aged ≤44 years old (AAPC=5.66%， P=0.087). ［Conclusion］ The incidence and mortality rates of oral and pharyngeal cancer in cancer registration areas of Hunan Province remain high and show an upward trend， with a tendency of younger onset. Males and middle-aged and elderly populations are the key focuses of prevention and control. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |