| 朱云峰,周 毅,高田静,等.2021年浙江省肿瘤登记地区结直肠癌发病与死亡特征及2000—2021年变化趋势分析[J].中国肿瘤,2025,34(10):783-791. |
| 2021年浙江省肿瘤登记地区结直肠癌发病与死亡特征及2000—2021年变化趋势分析 |
| Incidence and Mortality of Colorectal Cancer in Zhejiang Cancer Registration Areas in 2021 and Trends from 2000 to 2021 |
| 投稿时间：2025-04-29 |
| DOI：10.11735/j.issn.1004-0242.2025.10.A005 |
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| 中文关键词: 结直肠癌 发病率 死亡率 变化趋势 浙江 |
| 英文关键词:colorectal cancer incidence mortality trends Zhejiang |
| 基金项目:浙江省医药卫生科技计划（2024KY460）；浙江省自然科学基金（LQN25G030004）；浙江省博士后科研项目（ZJ2024074）；浙江省疾病预防控制科技计划（2025JK018） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2021年浙江省肿瘤登记地区结直肠癌的发病与死亡情况及2000—2021年变化趋势。［方法］ 共纳入浙江省22个符合质量标准的肿瘤登记处数据，分城乡及性别统计分析结直肠癌的粗发病（死亡）率、中标发病（死亡）率、世标发病（死亡）率、0~74岁累积发病（死亡）率等指标。2000—2021年变化趋势使用Joinpoint回归模型计算年度变化百分比（annual percentage change，APC）和平均年度变化百分比（average annual percentage change，AAPC）进行分析。［结果］ 2021年浙江省肿瘤登记地区结直肠癌新发病例数为12 265例，死亡病例4 323例。男性中标发病率（32.74/10万）和中标死亡率（10.11/10万）均明显高于女性（20.78/10万和5.99/10万）。城市地区结直肠癌中标发病率和中标死亡率（28.27/10万和8.06/10万）均高于农村地区（24.12/10万和7.85/10万）。2000—2021年浙江省结直肠癌年龄别发病率和死亡率整体随年龄增长呈上升趋势，年龄别发病率在80~84岁年龄组达发病高峰，峰值为219.63/10万，年龄别死亡率在85岁及以上年龄组达到死亡高峰，峰值为199.65/10万。2000—2021年浙江省肿瘤登记地区结直肠癌中标发病率呈上升趋势（AAPC=2.23%，P<0.001），中标死亡率变化趋势比较平稳（AAPC=0.78%，P=0.067）。［结论］ 浙江省近22年结直肠癌发病率呈持续上升趋势，应重视结直肠癌的健康教育和早筛工作。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the incidence and mortality of colorectal cancer in Zhejiang cancer registration areas in 2021 and its temporal trends from 2000 to 2021. ［Methods］ Data from 22 cancer registries in Zhejiang Province in 2021 that met the quality standards were included. The crude incidence/mortality rate， age-standardized incidence/mortality rates by Chinese standard population (ASIRC/ASMRC) and by world standard population (ASIRW/ASMRW)， and cumulative incidence (mortality) rate for 0~74 years old were calculated. Trends from 2000 to 2021 were analyzed using the Joinpoint regression model by calculating the annual percentage change (APC) and average annual percentage change (AAPC). ［Results］ In 2021， the number of new colorectal cancer cases in Zhejiang cancer registration areas was 12 265， with 4 323 deaths. ASIRC and ASMRC were significantly higher in men (32.74/105 and 10.11/105) than those in women (20.78/105 and 5.99/105). Urban areas showed higher ASIRC and ASMRC (28.27/105 and 8.06/105) than rural areas(24.12/105 and 7.85/105). The age-specific incidence and mortality rates of colorectal cancer in Zhejiang Province showed an increasing trend with age， with a peak of 219.63/105 in the age group of 80~84 years old. The age-specific mortality rate peaked in the age group of 85 years old and above， with a peak of 199.65/105. From 2000 to 2021， ASIRC in Zhejiang Province showed an upward trend (AAPC=2.23%， P＜0.001)，ASMRC showed a marginal increase (AAPC=0.78%， P=0.067). ［Conclusion］ The incidence of colorectal cancer in Zhejiang Province had been on a continuous rise in the past 22 years， and health education and early screening should be emphasized. |
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