| 朱夏燕,陶欢青,王 乐,等.2021年浙江省肿瘤登记地区前列腺癌发病与死亡特征及2000—2021年变化趋势分析[J].中国肿瘤,2025,34(10):775-782. |
| 2021年浙江省肿瘤登记地区前列腺癌发病与死亡特征及2000—2021年变化趋势分析 |
| Incidence and Mortality of Prostate Cancer in Zhejiang Cancer Registration Areas in 2021 and Trends from 2000 to 2021 |
| 投稿时间：2025-05-21 |
| DOI：10.11735/j.issn.1004-0242.2025.10.A004 |
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| 中文关键词: 前列腺癌 发病率 死亡率 趋势分析 浙江 |
| 英文关键词:prostate cancer incidence mortality trend analysis Zhejiang |
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| 中文摘要: |
| 摘 要：［目的］ 分析2021年浙江省肿瘤登记地区前列腺癌发病与死亡特征及2000—2021年变化趋势。［方法］ 收集整理2000—2021年浙江省肿瘤登记地区前列腺癌发病与死亡数据，计算粗发病（死亡）率、中国人口标化率（简称中标率）、世界人口标化率（简称世标率）、0~74岁累积率等。采用Joinpoint回归模型计算年度变化百分比（annual percentage change，APC）和平均年度变化百分比（average annual percentage change，AAPC）等指标分析发病和死亡趋势。 ［结果］ 2021年浙江省肿瘤登记地区前列腺癌新发病例数为6 683例，粗发病率和中标发病率分别为61.21/10万和26.78/10万。2021年浙江省肿瘤登记地区前列腺癌死亡病例为1 036例，粗死亡率和中标死亡率分别为9.49/10万和3.28/10万。2000—2021年，浙江省肿瘤登记地区共报告前列腺癌新发病例30 876例，粗发病率为25.50/10万，中标发病率为13.35/10万。2000—2021年，浙江省肿瘤登记地区共报告前列腺癌死亡病例7 458例，粗死亡率为6.16/10万，中标死亡率为2.82/10万。城市地区前列腺癌中标发病率（13.58/10万）高于农村地区（12.84/10万），但中标死亡率（2.60/10万）低于农村地区（3.33/10万）。2000—2021年浙江省肿瘤登记地区前列腺癌中标发病率和中标死亡率总体均呈显著上升趋势（发病率：AAPC=13.88%，95%CI：11.43%~16.08%，P<0.001；死亡率：AAPC=4.35%，95%CI：2.21%~6.18%，P<0.001）。［结论］ 浙江省肿瘤登记地区前列腺癌发病呈快速上升趋势，死亡负担在农村地区更为严峻。需重点关注农村中老年男性群体，强化三级预防策略（风险干预、早期筛查与规范治疗），以降低疾病负担。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the incidence and mortality of prostate cancer in Zhejiang cancer registration areas in 2021 and the trends from 2000 to 2021. ［Methods］ Data of prostate cancer incidence and mortality in Zhejiang cancer registration areas from 2000 to 2021 were collected. The crude incidence/mortality rates， age-standardized incidence/mortality rates by Chinese standard population (ASIRC/ASMRC) and world standard population (ASIRW/ASMRW)， cumulative rates (0~74 years old) were calculated. Joinpoint regression model was used to estimate the annual percentage change(APC) and average annual percentage change(AAPC) to assess trends. ［Results］ In 2021， 6 683 new prostate cancer cases were reported in Zhejiang cancer registration areas， the crude incidence rate and ASIRC of prostate cancer were 61.21/105 and 26.78/105， respectively. The number of prostate cancer deaths was 1 036， the crude mortality rate and ASMRC were 9.49/105 and 3.28/105， respectively. From 2000 to 2021， a total of 30 876 new prostate cancer cases and 7 458 deaths were reported. The average crude incidence rate was 25.50/105， and the ASIRC was 13.35/105； the crude mortality rate and ASMRC rates were 6.16/105 and 2.82/105， respectively. The ASIRC was higher in urban areas (13.58/105) than that in rural areas (12.84/105)， while the ASMRC was lower in urban areas (2.60/105) than that in rural areas (3.33/105). From 2000 to 2021， both the ASIRC and ASMRC showed significant upward trends in Zhejiang cancer registration areas with AAPC of 13.88% (95%CI： 11.43%~16.08%， P<0.001) and 4.35% (95%CI：2.21%~6.18%， P<0.001)， respectively. ［Conclusion］ Prostate cancer incidence in Zhejiang Province had risen rapidly in last two decades， with rural areas facing a heavier mortality burden. Special attention should be paid to the elderly male population in rural areas， and the three-level prevention strategy should be strengthened to reduce the disease burden. |
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