| 李 妍,黄泓睿,马 旭.2021年浙江省肿瘤登记地区女性乳腺癌发病与死亡特征及2000—2021年变化趋势分析[J].中国肿瘤,2025,34(10):764-774. |
| 2021年浙江省肿瘤登记地区女性乳腺癌发病与死亡特征及2000—2021年变化趋势分析 |
| Incidence and Mortality of Female Breast Cancer in Zhejiang Cancer Registration Areas in 2021 and Trends from 2000 to 2021 |
| 投稿时间：2025-04-27 |
| DOI：10.11735/j.issn.1004-0242.2025.10.A003 |
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| 中文关键词: 乳腺癌 女性 发病率 死亡率 趋势 浙江 |
| 英文关键词:breast cancer female incidence mortality trend Zhejiang |
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| 中文摘要: |
| 摘 要：［目的］ 分析2021年浙江省肿瘤登记地区女性乳腺癌的发病和死亡情况及2000—2021年变化趋势。［方法］ 收集2000—2021年浙江省肿瘤登记地区上报的女性乳腺癌发病、死亡及人口资料，分城乡计算相应的粗发病率、粗死亡率、中国人口标化率（中标率）、世界人口标化率（世标率）、0～74 岁累积率、35～64 岁截缩率、构成比和年龄别率等。利用Joinpoint软件计算2000—2021年浙江省女性乳腺癌发病率和死亡率的平均年度变化百分比（average annual percentage change，AAPC）。［结果］ 2021年浙江省肿瘤登记地区女性乳腺癌新发病例数为7 262例，在女性全部恶性肿瘤发病中占比12.70%，粗发病率、中标发病率和世标发病率分别为65.71/10万、42.03/10万和39.22/10万，0~74岁累积发病率为4.26%，35~64岁截缩率为98.34/10万。城市和农村地区女性乳腺癌中标发病率分别为43.15/10万和40.15/10万。女性乳腺癌死亡病例数为992例，占女性全部恶性肿瘤死亡的6.97%，粗死亡率、中标死亡率和世标死亡率分别为8.98/10万、4.62/10万和4.47/10万，0~74岁累积死亡率为0.48%，35~64岁截缩率为8.89/10万。城市和农村地区女性乳腺癌中标死亡率分别为4.79/10万和4.34/10万。2021年女性乳腺癌发病高峰在60~64岁年龄组，死亡高峰在85岁及以上年龄组。2000—2021年浙江省肿瘤登记地区女性乳腺癌粗发病率、中标发病率和世标发病率均呈现明显上升趋势（P均＜0.05）。女性乳腺癌粗死亡率和世标死亡率也呈现上升趋势（P均＜0.05）。［结论］ 2021年浙江省女性乳腺癌的发病率高于全国平均水平，而死亡率低于全国平均水平，发病和死亡特征均存在明显的城乡差异。2000—2021年女性乳腺癌发病与死亡均呈现上升趋势。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the incidence and mortality of female breast cancer in Zhejiang cancer registration areas in 2021 and the trends from 2000 to 2021. ［Methods］ The data of cancer incidence， mortality and population data reported by cancer registration areas in Zhejiang Province from 2000 to 2021 were collected. The crude incidence/mortality rates， age-standardized rates adjusted by Chinese standard population (ASIRC， ASMRC) and world standard population (ASIRW， ASMRW)，cumulative rates (0~74 years old)，truncated rates (35~64 years old) ， proportion of female breast cancer and age-specific rate were calculated. The average annual percentage change (AAPC) of female breast cancer incidence and mortality rates in Zhejiang from 2000 to 2021 was calculated using Joinpoint software. ［Results］ In 2021， there were 7 262 new cases of female breast cancer in Zhejiang cancer registration areas， accounting for 12.70% of all new female cancer cases. The crude incidence rate， ASIRC and ASIRW were 65.71/105， 42.03/105 and 39.22/105， respectively. The cumulative incidence rate (0~74 years old) was 4.26%， and the truncated rate (35~64 years old) was 98.34/105. The ASIRC in urban and rural areas were 43.15/105 and 40.15/105， respectively. There were 992 deaths of female breast cancer， accounting for 6.97% of all female cancer deaths. The crude mortality rate， ASMRC and ASMRW were 8.98/105， 4.62/105 and 4.47/105， respectively. The cumulative mortality rate (0~74 years old) was 0.48%， and the truncated rate (35~64 years old) was 8.89/105. The ASMRC in urban and rural areas were 4.79/105 and 4.34/105， respectively. The incidence rate of female breast cancer reached the peak at the age group of 60~64 years old， and the mortality rate reached the peak at the age group of 85 years old and above. From 2000 to 2021， the crude incidence rate， ASIRC and ASIRW of female breast cancer in Zhejiang cancer registration areas showed significant increasing trends (all P＜0.05). The crude mortality rate and ASMRW of female breast cancer also showed significant increasing trends (all P＜0.05). ［Conclusion］ The incidence rate of female breast cancer in Zhejiang Province was higher than the national average， while the mortality rate was lower than the national average in 2021. Both the incidence and mortality rates showed increasing trends from 2000 to 2021. Furthermore， distinct urban-rural disparities existed in both incidence and mortality characteristics. |
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