项彩英,陈 颖,汪德兵,等.2021年浙江省肿瘤登记地区甲状腺癌发病与死亡特征及2000—2021年变化趋势分析[J].中国肿瘤,2025,34(10):756-763.
2021年浙江省肿瘤登记地区甲状腺癌发病与死亡特征及2000—2021年变化趋势分析
Incidence and Mortality of Thyroid Cancer in Zhejiang Cancer Registration Areas in 2021 and Trends from 2000 to 2021
投稿时间:2025-05-19  
DOI:10.11735/j.issn.1004-0242.2025.10.A002
中文关键词:  甲状腺癌  发病率  死亡率  变化趋势  浙江
英文关键词:thyroid cancer  incidence rate  mortality rate  trend  Zhejiang
基金项目:
作者单位
项彩英 开化县疾病预防控制中心 
陈 颖 南京医科大学公共卫生学院 浙江省肿瘤医院浙江省肿瘤防治办公室 
汪德兵 开化县疾病预防控制中心 
谢 丽 开化县疾病预防控制中心 
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中文摘要:
      摘 要:[目的] 分析2021年浙江省肿瘤登记地区甲状腺癌发病与死亡特征及2000—2021年变化趋势。[方法] 基于浙江省22个肿瘤登记处的2000—2021年登记数据,分城乡、性别统计分析甲状腺癌的粗发病(死亡)率、中标发病(死亡)率、世标发病(死亡)率、0~74岁累积发病(死亡)率及35~64岁截缩率等指标。利用Joinpoint回归模型计算甲状腺癌发病率和死亡率的年度变化百分比(annul percentage change,APC)及平均年度变化百分比(average annual percentage change,AAPC)及其95%置信区间(confidence interval,CI),分析时间趋势特征。[结果] 浙江省肿瘤登记地区甲状腺癌粗发病率从2000年的3.62/10万升至2021年的79.66/10万,中标发病率从3.11/10万升至69.49/10万(AAPC=15.55%,95%CI:14.65%~16.61%)。女性中标发病率增速(AAPC=15.54%,95%CI:14.71%~16.49%)略高于男性(AAPC=15.02%,95%CI:13.53%~16.82%)。农村地区中标发病率增速(AAPC=23.34%,95%CI:21.48%~25.33%)显著高于城市(AAPC=14.12%,95%CI:13.15%~15.43%)。15~44岁群体粗发病率增速最快(AAPC=20.37%,95%CI:18.46%~22.31%),其次为45~64岁群体(AAPC=18.41%,95%CI:16.65%~20.19%)。2000—2021年,浙江省肿瘤登记地区甲状腺癌粗死亡率波动上升,从0.34/10万升至0.56/10万(AAPC=5.52%,95%CI:3.45%~7.70%),中标死亡率变化平稳。[结论] 2000—2021年浙江省肿瘤登记地区甲状腺癌发病率显著增长,尤其在女性及中青年人群中增速明显,而中标死亡率相对稳定。
英文摘要:
      Abstract:[Purpose] To analyze the incidence and mortality of thyroid cancer in Zhejiang cancer registration areas in 2021 and trends from 2000 to 2021. [Methods] Based on cancer data from 22 registries across Zhejiang Province between 2000 and 2021, the crude incidence/mortality rates, age-standardized incidence/mortality rates of thyroid cancer by Chinese and world standard population (ASIRC/ASMRC, ASIRW/ASMRW), cumulative rate (0~74 years old) and truncated rate (35~64 years old) were analyzed. Joinpoint regression model was employed to calculate the annual percentage change (APC) and average annual percentage change (AAPC) with 95% confidence interval (CI) for analyzing trends of thyroid cancer incidence and mortality rates from 2000 to 2021. [Results] The crude incidence rate of thyroid cancer increased from 3.62/105 in 2000 to 79.66/105 in 2021, and ASIRC rose from 3.11/105 to 69.49/105 (AAPC=15.55%, 95%CI: 14.65%~16.61%). The AAPC for ASIRC was slightly higher in female (15.54%, 95%CI: 14.71%~16.49%) than that in male (15.02%, 95%CI: 13.53%~16.82%). The increase was significantly more pronounced in rural areas (AAPC=23.34%, 95%CI: 21.48%~25.33%) compared to urban areas (AAPC=14.12%, 95%CI: 13.15%~15.43%). Among age groups, the age group of 15~44 years old showed the fastest increase in crude incidence rate (AAPC=20.37%, 95%CI: 18.46%~22.31%), followed by the age group of 45~64 years old (AAPC=18.41%, 95%CI: 16.65%~20.19%). Between 2000 and 2021, the crude mortality rate of thyroid cancer rose from 0.34/105 to 0.56/105(AAPC=5.52%, 95%CI:3.45%~7.70%), the trend of ASMRC was relatively stable. [Conclusion] From 2000 to 2021, the incidence of thyroid cancer in Zhejiang Province increased markedly, especially among females and younger to middle-aged adults, while the age-standardized mortality rate remained stable.
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