| 陈兴龙,张乐蒙,程田力,等.基于分子探针的肿瘤诊疗技术研究进展[J].中国肿瘤,2025,34(9):724-733. |
| 基于分子探针的肿瘤诊疗技术研究进展 |
| Research Progress of Tumor Diagnosis and Treatment Technology Based on Molecular Probes |
| 投稿时间：2025-04-25 |
| DOI：10.11735/j.issn.1004-0242.2025.09.A006 |
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| 中文关键词: 分子探针 肿瘤诊疗 体内成像 肿瘤生物标志物 |
| 英文关键词:molecular probes tumor diagnosis and treatment in vivo imaging tumor biomarkers |
| 基金项目:湖南省自然科学基金 （2023JJ60039）；长沙市自然科学基金（Kq2208150）；吴阶平基金项目 （320.6750. 2023-05-88）；“科研攀登计划”NSFC（国自）培育基金 （2023NSFC-A006） |
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| 摘要点击次数: 288 |
| 全文下载次数: 125 |
| 中文摘要: |
| 摘 要：肿瘤作为威胁人类健康的主要疾病之一，其早期精准诊断与定位是制订有效治疗方案的关键。近年来，分子探针（molecular probes，MPs）在生物成像领域取得显著进展，凭借高灵敏度、高特异度及无创性等优势，已成为肿瘤诊疗领域的研究热点。全文系统综述了 MPs 在肿瘤诊疗中的应用，涵盖其分类（如荧光、光声、化学发光、生物发光及多模态探针等）、设计策略（包括主动/被动靶向机制、识别单元-成像单元-信号转化单元-治疗单元的协同构建）及检测原理，并重点阐述了基于酶、受体、活性物质及肿瘤微环境等的 MPs 研发进展。同时，全文强调多功能整合及多模态成像的优势，分析了 MPs 在临床转化中面临的挑战（如生物相容性、配套设备优化等），旨在为开发高性能 MPs 提供思路，推动肿瘤精准个性化诊疗的发展。 |
| 英文摘要: |
| Abstract： As one of the major diseases threatening human health， the early accurate diagnosis and localization of tumors are crucial for formulating effective treatment plans. In recent years， molecular probes (MPs) have made significant progress in the field of biological imaging. With advantages such as high sensitivity， high specificity， and non-invasiveness， they have become a research hotspot in the field of tumor diagnosis and treatment. This paper systematically reviews the applications of MPs in tumor diagnosis and treatment， covering their classifications (such as fluorescent， photoacoustic， chemiluminescent， bioluminescent， and multimodal probes)， design strategies (including active/passive targeting mechanisms and the synergistic construction of identification units， imaging units， signal conversion units and treatment units)， as well as detection principles. It also focuses on elaborating the research progress of MPs based on enzymes， receptors， reactive substances， and tumor microenvironment. Meanwhile， this paper emphasizes the advantages of multifunctional integration and multimodal imaging， and analyzes the challenges faced by MPs in clinical translation(such as biocompatibility and optimization of supporting equipment). It aims to provide ideas for the development of high-performance MPs and promote the advancement of precise and personalized tumor diagnosis and treatment. |
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