| 宋东峰,由婷婷,唐 辉,等.靶向自噬在胰腺癌治疗中的研究进展[J].中国肿瘤,2025,34(8):653-659. |
| 靶向自噬在胰腺癌治疗中的研究进展 |
| Research Progress on Targeting Autophagy in Pancreatic Cancer Treatment |
| 投稿时间：2025-03-10 |
| DOI：10.11735/j.issn.1004-0242.2025.08.A007 |
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| 中文关键词: 自噬 胰腺癌 化学药物治疗 靶向治疗 免疫治疗 |
| 英文关键词:autophagy pancreatic cancer chemotherapy targeted therapy immunotherapy |
| 基金项目:中央高水平医院临床科研专项（2022-PUMCH-D-001）；中国医学科学院医学与健康科技创新工程（2023-I2M-2-002） |
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| 中文摘要: |
| 摘 要：自噬是细胞自我降解维持稳态的过程，在肿瘤晚期发挥促瘤功能，而胰腺癌细胞及其周围的基质细胞中存在较高水平的自噬，因此靶向自噬成为胰腺癌很有前景的治疗方法。全文围绕靶向自噬在胰腺癌治疗中的研究，介绍自噬在胰腺癌细胞增殖、转移、免疫微环境及耐药的作用及机制，并简述靶向自噬及联合治疗在胰腺癌中的临床前及临床研究，以期为胰腺癌治疗提供新的理论依据和治疗策略。 |
| 英文摘要: |
| Abstract：Autophagy is a cellular self-degradation process that maintains homeostasis and has been shown to promote tumor progression in advanced stages. Pancreatic cancer cells and the surrounding stromal cells exhibit high levels of autophagy. Therefore， targeting autophagy has emerged as a promising therapeutic strategy for pancreatic cancer. This review focuses on research targeting autophagy in pancreatic cancer treatment， elaborating on the roles and underlying mechanisms of autophagy in pancreatic cancer cell proliferation， metastasis， modulation of the tumor immune microenvironment， and drug resistance. Additionally， we summarize preclinical and clinical studies investigating autophagy-targeted therapies both as monotherapy and in combination with other treatments， aiming to provide new theoretical rationale and therapeutic strategies for pancreatic cancer management. |
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