| 丁璐璐,徐源佑,陈永胜,等.全球结直肠癌流行现状与人类发展指数关系分析[J].中国肿瘤,2025,34(8):611-617. |
| 全球结直肠癌流行现状与人类发展指数关系分析 |
| Global Epidemic Status of Colorectal Cancer and Relationship of Colorectal Cancer ?注urden with the Human Development Index |
| 投稿时间：2024-08-13 |
| DOI：10.11735/j.issn.1004-0242.2025.08.A002 |
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| 中文关键词: 结直肠癌 发病率 死亡率 人类发展指数 |
| 英文关键词:colorectal cancer incidence rate mortality rate human development index |
| 基金项目:南通市“十四五”科教强卫工程（通卫科技［2021］15号） |
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| 摘要点击次数: 355 |
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| 中文摘要: |
| 摘 要： ［目的］ 分析全球结直肠癌疾病负担分布流行现状，探讨人类发展指数（human develop-ment index，HDI）与结直肠癌疾病负担的关系。［方法］ 基于GLOBOCAN 2022估计数据，分析结直肠癌在不同地区、国家和HDI水平的疾病负担差异。采用Spearman秩检验探索HDI与结直肠癌疾病负担之间的相关性。［结果］ 2022年全球结直肠癌发病估计数为1 926 425例（男性1 069 446例，女性856 979例），标化发病率为18.4/10万（男性21.9/10万，女性15.2/10万），累积发病风险为2.10%（男性2.60%，女性1.70%）；死亡估计数为904 019例（男性499 775例，女性404 244例），标化死亡率为8.1/10万（男性9.9/10万，女性6.5/10万），累积死亡风险为0.84%（男性1.00%，女性0.65%）；1-粗死亡率/粗发病率（mortality rate/ crude incidence rate，M/I）为0.53（男性0.53，女性0.53），不同地区和国家之间的疾病负担差距较大。按HDI不同水平分组后显示，极高、高、中和低HDI地区标化发病率依次为28.6/10万、18.1/10万、6.7/10万和6.4/10万，标化死亡率依次为10.5/10万、8.3/10万、3.9/10万和4.5/10万，1-M/I依次为0.57、0.52、0.43和0.30，且不同等级HDI水平的年龄组发病率和死亡率均随年龄增长而不断上升。Spearman相关性分析显示，HDI与结直肠癌的标化发病率（r=0.84）、标化死亡率（r=0.71）和1-M/I（r=0.82）均呈正相关（P均<0.001）。［结论］ 从全球范围看，结直肠癌负担仍然较重，不同国家和地区呈现不同的负担模式，且与发展水平呈正相关，制定与自身医疗资源相匹配的防治策略，有助于降低结直肠癌的发病及死亡风险。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze global epidemic status of colorectal cancer and explore the relationship between the human development index (HDI) and the burden of colorectal cancer. ［Methods］ Based on the GLOBOCAN 2022 estimation data， the disease burden of colorectal cancer in different regions， countries， and levels of HDI were analyzed. Spearman’s rank test was used to explore the correlation between HDI and colorectal cancer disease burden. ［Results］ The estimated global incidence of colorectal cancer in 2022 was 1 926 425 cases (1 069 446 for male and 856 979 for female)， with a age-standardized incidence rate of 18.4/105 (21.9/105 for male and 15.2/105 for female)， and cumulative risk of incidence of 2.10% (2.60% for male and 1.70% for female)； the estimated number of deaths was 904 019 (499 775 for male and 404 244 for female)， with a age-standardized mortality rate of 8.1/105 (9.9/105 for male and 6.5/105 for female) and cumulative risk of death of 0.84% (1.00% for male and 0.65% for female). 1-crude mortality rate/ crude incidence rate (1-M/I) was 0.53 (0.53 for male and 0.53 for female). Large disparities were in the disease burden of colorectal cancer between different regions and countries. After grouped by HDI， we found that the age-standardized incidence rates in very high， high， median， and low HDI regions were 28.6/105， 18.1/105， 6.7/105， and 6.4/105， and the standardized mortality rates were 10.5/105， 8.3/105， 3.9/105， and 4.5/105， with 1-M/I of 0.57， 0.52， 0.43 and 0.30， respectively； and the incidence and mortality rates were increasing with age. Spearman’s correlation analysis showed a strong positive correlation between HDI and colorectal cancer in age-standardized ncidence (r=0.84)， age-standardized mortality (r=0.71) and 1-M/I (r=0.82) (all P<0.001). ［Conclusion］ The global burden of colorectal cancer remains high. There are disparities in the disease burden among countries and regions， which is positively correlated with their HDI levels， indicating that the colorectal cancer prevention and treatment strategies should be developed based on the conditions of each regions and countries accordingly. |
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