江玉蓉,王梓宇,凌 锐,等.循环肿瘤DNA在食管癌诊疗中的应用及最新进展[J].中国肿瘤,2025,34(5):391-396. |
循环肿瘤DNA在食管癌诊疗中的应用及最新进展 |
Application and Advances on Circulating Tumor DNA in Esophageal Cancer |
投稿时间:2024-12-05 |
DOI:10.11735/j.issn.1004-0242.2025.05.A009 |
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中文关键词: 食管癌 循环肿瘤DNA 诊断 治疗 |
英文关键词:esophageal cancer circulating tumor DNA diagnosis treatment |
基金项目:江苏省卫生健康委员会医学科研重点项目(ZDB2020022);镇江市社会发展指导性科技计划项目(FZ2023049) |
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中文摘要: |
摘 要:食管癌是全球最常见的恶性肿瘤之一,其早期诊断困难、个体疗效差异大,以及肿瘤残留和复发率高,均是目前临床治疗中的挑战。循环肿瘤DNA(circulating tumor DNA,ctDNA)是一种新兴的液体活检标志物,可以反映肿瘤负荷以及基因特征,具有无创性、可重复性及实时动态监测的优势,为食管癌的精准诊疗提供了新的途径。近年来,ctDNA在食管癌早期诊断、疗效预测、预后评估、肿瘤残留及复发监测方面取得显著进展,逐渐成为食管癌诊疗中的重要工具。全文总结了ctDNA在食管癌研究中的最新进展,为未来的研究与临床应用提供参考。 |
英文摘要: |
Abstract: Esophageal cancer is one of the most prevalent malignant tumors globally. Its clinical management is challenged by difficulties in early diagnosis, significant inter-individual variability in therapeutic efficacy, and high rates of tumor residuals and recurrence. Circulating tumor DNA (ctDNA), a novel liquid biopsy biomarker, reflects tumor burden and genetic characteristics. It offers advantages such as non-invasiveness, repeatability, and real-time dynamic monitoring, providing a promising approach for precision diagnosis and treatment of esophageal cancer. In recent years, ctDNA has shown remarkable progress in the early detection, efficacy prediction, prognostic assessment, and monitoring of tumor residuals and recurrence in esophageal cancer, emerging as an essential tool in the clinical management of the disease. This review summarizes the latest advancements in ctDNA research in esophageal cancer, providing valuable insights and inspiration for future studies and clinical applications. |
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