| 孙 倩,胡军国,刘玉琴,等.2020年甘肃省肿瘤登记地区胰腺癌流行特征及2010—2020年变化趋势分析[J].中国肿瘤,2025,34(5):377-384. |
| 2020年甘肃省肿瘤登记地区胰腺癌流行特征及2010—2020年变化趋势分析 |
| Epidemiological Characteristics of Pancreatic Cancer in 2020 and Its Change Trend from 2010 to 2020 in Cancer Registration Areas of Gansu Province |
| 投稿时间：2024-10-14 |
| DOI：10.11735/j.issn.1004-0242.2025.05.A007 |
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| 中文关键词: 胰腺癌 流行特征 变化趋势 甘肃 |
| 英文关键词:pancreatic cancer epidemic characteristics change trend Gansu |
| 基金项目:中国消化道早癌医师共同成长计划科研项目（GTCZ-2022-GS-62-0004） |
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| 摘要点击次数: 29 |
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| 中文摘要: |
| 摘 要：［目的］ 分析甘肃省肿瘤登记地区2020年胰腺癌发病和死亡情况及2010—2020年变化趋势。［方法］ 整理2010—2020年甘肃省肿瘤登记地区胰腺癌的数据，计算胰腺癌的粗发病（死亡）率、中标发病（死亡）率、世标发病（死亡）率、0~74岁累积率、构成比等。采用Joinpoint 4.7.0软件计算2010—2020年甘肃省肿瘤登记地区胰腺癌中标率的平均年度变化百分比（average annual percentage change，AAPC）。［结果］ 2020年甘肃省肿瘤登记地区共报告胰腺癌发病838例，粗发病率为6.52/10万，中标发病率和世标发病率分别为4.03/10万、4.49/10万，占所有恶性肿瘤总发病数的2.50%；2020年甘肃省肿瘤登记地区共报告胰腺癌死亡702例，粗死亡率为5.46/10万，中标死亡率和世标死亡率分别为3.25/10万、3.73/10万，占所有恶性肿瘤总死亡数的3.98%。2010—2020年甘肃省肿瘤登记地区共报告胰腺癌发病2 413例，粗发病率为5.28/10万，中标发病率为4.18/10万，世标发病率为4.63/10万，0~74岁累积率为0.49%。2010—2020年甘肃省肿瘤登记地区共报告胰腺癌死亡1 871例，粗死亡率为3.92/10万，中标死亡率为3.09/10万，世标死亡率为3.50/10万，0~74岁累积率为0.36%。分性别和地区来看，2010—2020年胰腺癌发病率和死亡率均表现为男性高于女性，农村地区高于城市地区。2010—2020年间，甘肃省肿瘤登记地区胰腺癌发病率和死亡率都表现为44岁以下处于较低水平，45岁开始出现明显上升的趋势，在80~84岁组达到峰值。2010—2020年甘肃省肿瘤登记地区胰腺癌中标发病率上升，AAPC为0.411%，但变化趋势无统计学意义（P＞0.05）；胰腺癌中标死亡率呈升高趋势，AAPC为6.515%，变化趋势有统计学意义（P=0.014）。［结论］ 2010—2020年甘肃省胰腺癌中标发病率保持平稳，中标死亡率逐年上升，发病率和死亡率都表现为男性高于女性，农村高于城市地区。农村地区中老年男性人群是胰腺癌防治的重点人群，需开展有针对性的防控措施。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and mortality of pancreatic cancer in 2020 and the change trend from 2010 to 2020 in cancer registration areas of Gansu Province. ［Methods］ The data of pancreatic cancer from 2010 to 2020 were collected from cancer registries in Gansu Province. The crude incidence/mortality rate， age-standardized incidence/mortality rate by Chinese standard population (ASIRC/ASMRC) and world standard population (ASIRW/ASMRW) ， 0~74 years old cumulative rate and proportion of pancreatic cancer were calculated. Joinpoint 4.7.0 software was used to calculate the average annual percentage change (AAPC) of ASIRC/ASMRC of pancreatic cancer in cancer registration areas of Gansu Province from 2010 to 2020. ［Results］ In 2020， a total of 838 new cases of pancreatic cancer were reported in the cancer registration areas of Gansu Province， with a crude incidence rate of 6.52/105， ASIRC and ASIRW of 4.03/105 and 4.49/105 respectively， accounting for 2.50% of all malignant tumor incidence. In 2020， 702 cases of pancreatic cancer deaths were reported in the cancer registration areas of Gansu Province， with a crude mortality rate of 5.46/105， ASMRC and ASMRW of 3.25/105 and 3.73/105， respectively， accounting for 3.98% of all malignant tumor deaths. From 2010 to 2020， a total of 2 413 cases of pancreatic cancer were reported in cancer registration areas in Gansu Province， accounting for 1.90% of all malignant tumors in the province. The crude incidence rate of pancreatic cancer was 5.28/105， the ASIRC was 4.18/105， the ASIRW was 4.63/105， and the cumulative rate of 0~74 years old was 0.49%. From 2010 to 2020， a total of 1 871 pancreatic cancer deaths were reported in cancer registration areas of Gansu Province， accounting for 2.38% of all malignant tumor deaths in the province. The crude mortality rate was 3.92/105， the ASMRC was 3.09/105， the ASMRW was 3.50/105， and the cumulative rate of 0~74 years old was 0.36%. In terms of sex and region， the incidence and mortality of pancreatic cancer from 2010 to 2020 in men were higher than those in women， and higher in rural areas than those in urban areas. From 2010 to 2020， the incidence and mortality were at a low level under the age of 44 years old， and increased significantly after 45 years old， reaching a peak in the age group of 80~84 years old. ASIRC showed no significant change from 2010 to 2020 with an AAPC of 0.411%(P>0.05). From 2010 to 2020， the ASMRC showed an significantly increasing trend with an AAPC of 6.515% (P=0.014). ［Conclusion］ From 2010 to 2020， the ASRIC of pancreatic cancer in Gansu Province showed no significant change， while the ASMRC showed a significantly increasing trend. The incidence and mortality rates were higher in men than those in women and higher in rural areas than those in urban areas. Middle-aged and elderly men in rural areas are the key groups of prevention and treatment of pancreatic cancer， so targeted prevention and control measures should be carried out. |
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