| 樊与蔓,李云西,赵江世,等.2019年广西壮族自治区扶绥县肝癌流行特征及2011—2019年变化趋势分析[J].中国肿瘤,2025,34(3):195-202. |
| 2019年广西壮族自治区扶绥县肝癌流行特征及2011—2019年变化趋势分析 |
| Incidence and Mortality of Liver Cancer in Fusui County of Guangxi Zhuang Autonomous Region in 2019 and Trend from 2011 to 2019 |
| 投稿时间：2024-08-29 |
| DOI：10.11735/j.issn.1004-0242.2025.03.A005 |
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| 中文关键词: 肝癌 发病率 死亡率 疾病负担 广西 |
| 英文关键词:liver cancer incidence mortality burden of disease Guangxi |
| 基金项目:广西医疗卫生适宜技术开放与推广应用项目（S2022112）；广西自然科学基金重点项目区域高发疾病研究联合专项资助（2024GXNSFDA010040）；南宁市青秀区科技计划重点研发计划项目（2022009） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2019年广西扶绥县肝癌流行特征及2011—2019年变化趋势。［方法］ 根据扶绥县2011—2019年肝癌发病与死亡数据，结合扶绥县户籍人口数据，计算粗发病率、粗死亡率、中国人口标准化率（简称中标率）、世界人口标准化率（简称世标率）、0~74岁累积率、伤残调整寿命年（disability?鄄adjusted life years，DALY）、早死寿命损失年（years of life lost，YLL）、伤残寿命损失年（years lived with disability，YLD）等指标。采用 Joinpoint线性回归模型计算2011—2019年扶绥县肝癌中标发病率、中标死亡率和DALYs 率的平均年度变化百分比（average annual percentage change，AAPC），分析其时间变化趋势。［结果］ 2019年广西扶绥县肝癌新发病例345例，死亡病例298例，分别占扶绥县全部恶性肿瘤新发和死亡病例的28.49%和35.86%。其中，粗发病率、中标发病率和世标发病率分别为74.71/10万、67.55/10万和65.63/10万；粗死亡率、中标死亡率、世标死亡率分别为64.53/10万、58.78/10万和56.88/10万。扶绥县2019年男性中标发病率与死亡率均高于女性（男性为105.32/10万、95.67/10万；女性为27.26/10万、19.11/10万）。发病率和死亡率高峰分别在65~69岁与80~84岁组。2011—2019年间，扶绥县肝癌中标发病率由2011年的82.50/10万下降至2019年的67.55/10万，年均降低3.01%（AAPC=-3.01%，P=0.024），但中标死亡率无明显变化趋势（AAPC=-1.44%，P=0.224）。DALY率则从14.51/10万降低至10.36/10 万，年均降低2.82%（AAPC=-2.82%，P=0.050）。［结论］ 2011—2019年广西扶绥县肝癌中标发病率和DALYs率均呈下降趋势，中标死亡率变化趋势平稳。但扶绥县肝癌发病率和死亡率仍保持较高水平，肝癌仍然是扶绥县重点防控的恶性肿瘤，须进一步加强对该区域人群尤其是男性及老年人的肝癌预防、筛查与早诊早治工作。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and mortality of liver cancer in Fusui County of Guangxi Zhuang Autonomous Region in 2019 and the trend of change from 2011 to 2019. ［Methods］ Based on the incidence and mortality data of liver cancer in Fusui County from 2011 to 2019， the crude incidence rate， crude mortality rate， age-standardized rate by Chinese standard population (ASIRC/ASMRC)， age-standardized rate by world standard population (ASMRW/ASMRW)， disability-adjusted life years (DALY)， years of life lost (YLL)， years of lived with disability (YLD) were calculated. The Joinpoint linear regression model was used to calculate the average annual percentage change (AAPC) of the ASIRC/ASMRC and DALY rate of liver cancer in Fusui County from 2011 to 2019. ［Results］ In 2019， there were 345 new cases and 298 deaths of liver cancer in Fusui County， accounting for 28.49% and 35.86% of all new cases and death cases of malignant tumors in Fusui County， respectively. The crude incidence rate， ASIRC and ASIRW were 74.71/105， 67.55/105 and 65.63/105， respectively; the crude mortality rate， ASMRC and ASMRW were 64.53/105， 58.78/105 and 56.88/105， respectively. In 2019， ASIRC/ASMRC of men were higher than those of women (105.32/105 and 95.67/105 for men; 27.26/105 and 19.11/105 for women). The peak incidence and mortality rates were in the 65~69 and 80~84 age groups， respectively. The incidence rate of liver cancer in Fusui County declined from 82.50/105 in 2011 to 67.55/105 in 2019， with an AAPC of -3.01% (P=0.024)， but the mortality rate did not have significant changes(AAPC=-1.44%，P=0.224). The rate of DALY decreased from 14.51/105 to 10.36/105， with an AAPC of -2.82% (P=0.050). ［Conclusion］ The incidence rate and DALY rate of liver cancer in Fusui County showed an overall decreasing trend from 2011 to 2019， but still remained at a high level. It is necessary to further strengthen the prevention， screening and early treatment of liver cancer in this region， especially for men and the elderly. |
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