| 骆文书,徐文超,周孟孟,等.2009—2019年江苏省肿瘤登记地区淋巴瘤发病趋势及年龄变化分析[J].中国肿瘤,2024,33(12):999-1005. |
| 2009—2019年江苏省肿瘤登记地区淋巴瘤发病趋势及年龄变化分析 |
| Trend Analysis on Incidence and Age at Diagnosis of Lymphoma in Cancer Registration Areas of Jiangsu Province from 2009 to 2019 |
| 投稿时间：2023-12-15 |
| DOI：10.11735/j.issn.1004-0242.2024.12.A006 |
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| 中文关键词: 淋巴瘤 发病年龄 平均年度变化百分比 发病率 趋势 江苏 |
| 英文关键词:lymphoma age at onset average annual percentage change incidence trend Jiangsu |
| 基金项目:国家重点研发计划（2016YFC1302603）；江苏省卫生计生委医学科研课题（H2017017）；常州市卫生健康委科技项目（ZD202350） |
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| 中文摘要: |
| 摘 要： ［目的］ 分析江苏省肿瘤登记地区2009—2019年淋巴瘤发病的时间趋势和发病年龄变化特征。 ［方法］ 选取江苏省疾病预防控制中心负责收集的有连续完整数据且各项指标均符合要求的16个登记处提交的2009—2019年肿瘤发病数据。计算淋巴瘤发病率及其中标率的平均年度变化百分比（average annual percentage change，AAPC）及95%置信区间（confidence interval，CI）。构建1929—2019年出生队列，分析不同时期出生人群的淋巴瘤发病率变化趋势。通过线性回归模型分析平均发病年龄随年代变化的趋势。［结果］ 2009—2019年江苏省肿瘤登记地区淋巴瘤发病率平均每年上升5.74%，男性发病率平均每年上升幅度（5.55%）高于女性（5.02%），城市地区发病率平均每年上升幅度（6.26%）高于农村地区（4.90%）。调整年龄结构后，淋巴瘤中标率平均每年上升3.40%，且女性中标率上升幅度（3.16%）高于男性（3.05%），城市地区中标率上升幅度（3.39%）依然高于农村地区（2.43%）。出生队列分析显示，淋巴瘤发病率在40岁前波动较大，无明显变化趋势，而40岁及以上各年龄组的发病率整体上均呈现上升趋势。2009—2019年江苏省肿瘤登记地区淋巴瘤平均发病年龄呈现上升趋势，平均每年增加0.35岁（P<0.001）；调整年龄结构后，淋巴瘤标化平均发病年龄平均每年增加0.15岁(P=0.016）。与2009年相比，2019年淋巴瘤的标化年龄别发病构成整体呈后移趋势，除70~74岁组外，60岁及以上各年龄组的标化发病构成由2009年的52.57%升高至2019年的56.16%。［结论］ 2009—2019年江苏省肿瘤登记地区淋巴瘤发病率呈现逐年升高趋势。平均发病年龄出现后移的趋势，且男性的后移趋势比女性更加明显。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the trend of incidence and mean age at diagnosis of lymphoma in cancer registration areas of Jiangsu Province from 2009 to 2019. ［Methods］ Continuous and completed data of cancer incidence from 2009 to 2019 were collected from 16 cancer registries in Jiangsu Province， and all indicators meeting the requirements. Joinpoint 4.7.0.0 software was used to analyze the trend of lymphoma incidence， the average annual percentage change (AAPC) and 95% confidence interval (CI) were calculated. A birth cohort was built from 1929 to 2019， to analyze the change trend of lymphoma incidence rate among people born in different periods. ［Results］ From 2009 to 2019， the AAPC of lymphoma incidence rate in cancer registration areas of Jiangsu Province was 5.74%， 5.55% for men and 5.02% for women. The AAPC in urban areas was higher than that in rural areas (6.26% vs 4.90%). The age-standardized incidence rate (ASIR) of lymphoma increased by 3.40% annually on average. The rising amplitude of ASIR of women (3.16%) was higher than that of men (3.05%)， and the rising amplitude of ASIR of lymphoma in urban areas (3.39%) was higher than that in rural areas (2.43%). The birth cohort analysis showed that the incidence rate of lymphoma fluctuated greatly before the age of 40， and there was no significant trend of change， while the incidence rate in age groups of 40 years old and above showed an overall upward trend. The average age at onset of lymphoma showed an upward trend from 2009 to 2019， with an average annual increase of 0.35 years old (P<0.001). The standardized average age at onset for lymphoma still showed a significant upward trend， with an average annual increase of 0.15 years old (P=0.016). Compared with 2009， the standardized age specific incidence of lymphoma in 2019 showed an overall backward trend， while the standardized incidence in all age groups after 60 years old (except for the age group of 70~74 years old) increased. The proportion of lymphoma in people above 60 years old was 56.16% in 2019， which was higher than that in 2009(52.57%). ［Conclusion］ The incidence rate of lymphoma in Jiangsu Province was increasing year by year from 2009 to 2019. The age at onset tended to shift back， and the trend was more pronounced in male than female. |
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