| 崔俊鹏,陆 艳,王临池,等.2009—2019年江苏省肿瘤登记地区膀胱癌发病趋势和年龄变化特征分析[J].中国肿瘤,2024,33(12):983-990. |
| 2009—2019年江苏省肿瘤登记地区膀胱癌发病趋势和年龄变化特征分析 |
| Trend Analysis on Incidence and Age at Diagnosis for Bladder Cancer in Cancer Registration Areas of Jiangsu Province from 2009 to 2019 |
| 投稿时间：2024-01-22 |
| DOI：10.11735/j.issn.1004-0242.2024.12.A004 |
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| 中文关键词: 膀胱癌 发病率 发病年龄 变化趋势 江苏 |
| 英文关键词:bladder cancer incidence rate age of onset trend analysis Jiangsu |
| 基金项目:江苏省老年健康科研项目（LKM2023038）；苏州市科技局民生科技（科技示范）项目（SS202010）；苏州市科技发展计划(医疗卫生科技创新)项目（SKYD2022007，SKYD2023161） |
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| 中文摘要: |
| 摘 要：［目的］分析2009—2019年江苏省肿瘤登记地区膀胱癌发病趋势及年龄变化情况。［方法］ 基于江苏省16个肿瘤登记处2009—2019年连续完整，且各项质控指标均合格的肿瘤登记资料，计算膀胱癌发病率、世界人口标化发病率（世标率）、年龄别发病率、平均发病年龄、标化平均发病年龄、年龄别发病构成比等指标。利用Joinpoint软件对发病趋势进行分析，计算平均年度变化百分比（average annual percentage change，AAPC）。构建出生队列模型，计算1929—2019年出生的男性和女性膀胱癌发病率，并分析其发病趋势。利用线性回归模型分析平均发病年龄、标化平均发病年龄与发病年份间的关系。［结果］ 江苏省肿瘤登记地区膀胱癌粗发病率由2009年的4.27/10万上升到2019年的7.04/10万，粗发病率和世标率均呈上升趋势（AAPC粗率=4.62%，AAPC世标率=1.92%，P均<0.001）。分性别来看，男性发病率上升幅度高于女性，男性发病率AAPC为5.32%，女性为1.98%。出生队列结果显示，60岁以上各年龄组人群的发病率随年份的增加呈明显上升趋势，其中80岁及以上年龄组增幅最快（AAPC=3.27%，P=0.007）。2009—2019年江苏省膀胱癌的平均发病年龄呈明显升高趋势，平均年增长0.17岁，调整年龄结构后，标化平均发病年龄无明显变化趋势。［结论］ 2009—2019年江苏省膀胱癌发病率呈上升趋势，男性发病率明显高于女性。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the trend of bladder cancer incidence and age at diagnosis in cancer registration areas of Jiangsu Province from 2009 to 2019. ［Methods］ The data of bladder cancer incidence from 2009 to 2019 were collected from 16 cancer registries in Jiangsu Province， and quality control indicators of the data were evaluated. The crude rate (CR) of incidence， age-standar-dized incidence rate by Segi world standard population (ASIRW)， age-specific incidence rate， mean age at diagnosis， mean standardized age at diagnosis， and age-specific incidence composition ratio were calculated. Incidence trends were analyzed using Joinpoint software and the average annual percentage change (AAPC) was calculated. Birth cohort models were constructed and cancer incidence rates were calculated for people born from 1929 to 2019 and the incidence trends were analyzed. The linear regression models were used to analyze the relationship of average age at onset， standardized average age of onset with year of onset. ［Results］ The CR of bladder cancer in Jiangsu Province increased from 4.27/105 in 2009 to 7.04/105 in 2019. The CR and ASIRW showed upward trends (CR： AAPC=4.62%， ASIRW： AAPC=1.92%， both P<0.001). Sex-specific analysis showed that the incidence rate was higher in male (AAPC=5.32%) than that in female (AAPC=1.98%). Birth cohort results indicated a significant upward trend in incidence rates among age groups of 60 years old above， and the fastest increase was in those aged 80 years old and above (AAPC=3.27%， P=0.007). From 2009 to 2019， the average age of bladder cancer onset in Jiangsu Province showed a significant rising trend， increasing by an average of 0.17 years old annually， but the standardized average age of onset showed no significant change after adjusting for age structure. ［Conclusion］ The incidence rate of bladder cancer showed an increasing trend from 2009 to 2019 in Jiangsu Province， with a significantly higher incidence rate in male than that in female. |
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