| 李卓颖,项永兵.代谢组学技术在肝癌病因学研究中的应用与进展[J].中国肿瘤,2024,33(11):952-959. |
| 代谢组学技术在肝癌病因学研究中的应用与进展 |
| Application and Progress of Metabolomics in the Etiology of Liver Cancer |
| 投稿时间：2024-04-02 |
| DOI：10.11735/j.issn.1004-0242.2024.11.A010 |
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| 中文关键词: 代谢组学 肝癌 队列研究 巢式病例-对照研究 危险因素 |
| 英文关键词:metabolomics liver cancer cohort study nested case-control study risk factor |
| 基金项目:国家重点研发计划项目（2021YFC2500404，2021YFC2500405） |
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| 摘要点击次数: 230 |
| 全文下载次数: 74 |
| 中文摘要: |
| 摘 要：代谢物作为生物体内化学反应的末端产物，是基因表达、蛋白质功能以及环境因素相互作用的最直接产物，能够综合反映生物体对内在遗传变异和外部环境变化的响应。代谢组学通过系统分析人体代谢物谱的改变，有助于发现潜在的生物标志物，为疾病的早期诊断、预防及个体化治疗提供新的思路。近年来，代谢组学技术在肝癌的病因研究中逐渐得到应用。全文对现有研究报道进行综述，以了解代谢组学技术在肝癌病因学研究中的应用，重点关注证据级别较高的前瞻性队列研究以及在队列基础上开展的巢式病例-对照研究等，归纳总结现有研究证据，为推动肝癌的病因学机制研究，了解已知危险因素的致病机制以及肝癌的风险预测提供重要的参考依据。 |
| 英文摘要: |
| Abstract： Metabolites， as the end products of biochemical reactions within organisms， directly reflect the interplay of gene expression， protein function， and environmental factors， offering a comprehensive reflection of the organism’s response to inherent genetic variations and external environmental changes. By systematically analyzing changes in human metabolite profiles， metabolomics aids in the identification of potential biomarkers， offering new insights for the early diagnosis， prevention， and personalized treatment of diseases. In recent years， research methodologies in metabolomics have increasingly been applied to the etiological studies of liver cancer. This paper aims to review existing research reports to understand the application of metabolomics in the study of liver cancer etiology， with a focus on high-level evidence from prospective cohort studies and case-control studies nested within cohorts. By summarizing the current research evidence， the paper aims to advance the study of the etiological mechanisms of liver cancer， understand the pathogenic mechanisms of known risk factors， and offer a scientific foundation for the prediction of liver cancer. |
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