| 张绍丽,曹毛毛,杨 帆,等.上消化道癌前病变患者健康相关生活质量评价及影响因素研究[J].中国肿瘤,2024,33(9):747-755. |
| 上消化道癌前病变患者健康相关生活质量评价及影响因素研究 |
| Study on Health-Related Quality of Life and Its Influencing Factors in Patients with Precancerous Lesions of the Upper Gastrointestinal Tract |
| 投稿时间：2024-04-23 |
| DOI：10.11735/j.issn.1004-0242.2024.09.A006 |
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| 中文关键词: 上消化道癌 癌前病变 生活质量 影响因素 |
| 英文关键词:upper gastrointestinal cancer precancerous lesions quality of life influencing factor |
| 基金项目:京津冀基础研究合作专项（J200017）；首都卫生发展科研专项（2024-1G-4023） |
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| 中文摘要: |
| 摘 要：［目的］ 调查上消化道癌前病变患者的生活质量，探究影响上消化道癌前病变患者生活质量的因素。［方法］ 选取在2021年5月至12月参加上消化道癌筛查随访的上消化道癌前病变患者，进行问卷调查和内镜检查。采用危险因素问卷收集社会人口学信息和临床信息，利用欧洲三水平五维生命质量量表（EuroQol five-dimensional three-level questionnaire，EQ-5D-3L）获取患者的健康相关生活质量，使用中国版EQ-5D-3L积分转换体系将健康状态转换为健康效用值，利用EQ-5D-3L视觉模拟评分刻度尺（visual analogue scale，VAS） 获得VAS评分。影响因素分析采用多重线性回归进行多因素分析。［结果］ 接受调查的上消化道癌前病变患者在EQ-5D五个维度中，存在中度及严重问题的比例分别为：行动能力1.2%、自我照顾能力1.2%、日常活动能力1.2%、疼痛/不舒服12.6%、焦虑/抑郁3.9%。上消化道癌前病变患者在疼痛/不舒服及焦虑/抑郁两个维度存在的问题最多。上消化道癌前病变患者VAS评分均值为（82.42±10.28）分，最低为0分，最高100分。效用值得分均值为（0.97±0.07）分，最低为0.42分，最高为1.00分。上消化道癌前病变患者两种健康相关生活质量得分的共同影响因素为教育程度、家庭年收入、城乡分布、是否有消化道疾病史、是否有消化道症状。［结论］ 上消化道癌前病变患者在疼痛/不舒服、焦虑/抑郁两维度存在困难较多，为了提高患者的生活质量，应通过综合措施进行干预，包括社会支持、心理治疗以及健康教育。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the quality of life of patients with precancerous lesions of the upper gastrointestinal tract， to explore the factors affecting the quality of life of patients with precancerous lesions of the upper gastrointestinal tract. ［Methods］ From May 2021 to December 2021， patients with upper gastrointestinal precancerous lesions who participated in the upper gastrointestinal cancer screening and follow-up were selected for questionnaire survey and endoscopic examination. The EuroQol five-dimensional three-level questionnaire(EQ-5D-3L) questionnaire was used to obtain patients’ health-related quality of life. The Chinese version of the EQ-5D-3L score conversion system was used to convert health status into health utility values， and the EQ-5D-3L visual analogue scale(VAS) was used to obtain VAS scores. Multiple linear regression was used for multivariate analysis. ［Results］ The proportions of patients with moderate and severe problems in the five dimensions of EQ-5D among the surveyed patients with upper gastrointestinal precancerous lesions were as follows： mobility of 1.2%， self-care of 1.2%， usual activities of 1.2%， pain/discomfort of 12.6%， anxiety/depression of 3.9%. Patients with upper gastrointestinal precancerous lesions had the most problems in pain/discomfort and anxiety/depression. The average VAS score of patients with precancerous lesions of upper gastrointestinal tract was 82.42±10.28. The lowest score was 0， and the highest score was 100. The average score of utility value was 0.97±0.07， the lowest was 0.42， and the highest was 1.00. The common influencing factors of the two health-related quality of life in patients with upper gastrointestinal precancerous lesions were education level， annual household income， urban and rural distribution， history of gastrointestinal disease， and gastrointestinal symptoms.［Conclusion］ Patients with precancerous lesions of the upper gastrointestinal tract have more difficulties in pain/discomfort and anxiety/depression. To improve the quality of life of patients， comprehensive measures should be taken， including social support， psychological intervention， and strengthening health education. |
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