陈培清,赵宇侠,阙祖俊.循环肿瘤细胞在肺癌转移防治中作用的研究进展[J].中国肿瘤,2024,33(8):661-667.
循环肿瘤细胞在肺癌转移防治中作用的研究进展
Advances on Implication of Circulating Tumor Cells in Prevention and Treatment of Lung Cancer Metastasis
投稿时间:2023-08-22  
DOI:10.11735/j.issn.1004-0242.2024.08.A007
中文关键词:  环肿瘤细胞  肺癌  转移  生物标志物  治疗靶点
英文关键词:circulating tumor cells  lung cancer  metastasis  biomarkers  therapeutic target
基金项目:国家自然科学基金(81803777,82174017)
作者单位
陈培清 上海健康医学院协同科研中心 
赵宇侠 上海健康医学院协同科研中心 
阙祖俊 上海中医药大学附属市中医医院肿瘤研究所 
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中文摘要:
      摘 要:转移是导致肺癌患者死亡的最主要原因,而目前临床上仍缺乏特异性有效的防治肺癌转移进而提高患者生存的治疗药物。循环肿瘤细胞(circulating tumor cells,CTCs)作为肿瘤转移的“种子”,其数目和表型的动态变化过程,可实时反映出患者体内转移的发生及进展。全文聚焦于CTCs在肺癌根治术后转移防治中的作用,探讨其作为转移风险评估和临床疗效评价的潜力。CTCs有望成为抗肿瘤转移治疗的新靶点,以期为肺癌转移防治提供思路。
英文摘要:
      Abstract: Metastasis is the main cause of death in lung cancer patients, but there is a lack of effective drugs for prevention and treatment of lung cancer metastasis currently. As the “seeds” of tumor metastasis, the number and phenotype dynamic changes of circulating tumor cells (CTCs) can reflect the occurrence and development of tumor metastasis in real time. This paper reviews the implication of CTCs in the metastasis of lung cancer, focusing on the detection of CTCs for metastasis risk assessment and clinical efficacy evaluation, and explores CTCs as a potential biomarker for prevention and treatment of lung cancer metastasis.
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