| 蔡家安,钟 良.基于肠道菌群及其代谢物的结直肠癌生物标志物的研究进展[J].中国肿瘤,2024,33(7):596-602. |
| 基于肠道菌群及其代谢物的结直肠癌生物标志物的研究进展 |
| Research Progress of Colorectal Cancer Biomarkers Based on Gut Microbiota and Its Metabolites |
| 投稿时间：2023-07-18 |
| DOI：10.11735/j.issn.1004-0242.2024.07.A011 |
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| 中文关键词: 结直肠癌 肠道菌群 代谢物 生物标志物 |
| 英文关键词:colorectal cancer gut microbiota metabolites biomarkers |
| 基金项目:上海市大学生创新创业计划（S202110246209）；复旦大学本科生学术研究资助计划（FDUROP）曦源项目（2020年）；复旦大学上海医学院本科生创新创业计划（QF2006） |
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| 中文摘要: |
| 摘 要：肠道菌群是人体内最大和最复杂的微生物群落，与人体健康和疾病密切相关。结直肠癌是一种常见的消化道恶性肿瘤，其发生与进展受到多种因素的影响，其中肠道菌群及其代谢物是重要的调节因素之一。肠道菌群及其代谢物可以通过影响宿主的免疫系统、代谢途径、表观遗传学和信号通路等，促进或抑制结直肠癌的发生及进展。因此，肠道菌群及其代谢物可以作为结直肠癌的生物标志物，用于结直肠癌的筛查、诊断、分期、预后评估和治疗反应监测等。全文对目前已发现的与结直肠癌相关的肠道菌群及其代谢物的检测方法和临床应用的优势、问题以及未来发展方向作一综述，旨在为基于肠道菌群及其代谢物的结直肠癌防治提供参考。 |
| 英文摘要: |
| Abstract： The gut microbiota is the largest and most complex microbial community in the human body， which is closely related to human health and disease. Colorectal cancer (CRC) is a common malignant tumor of the digestive tract influenced by various factors， among which the gut microbiota and its metabolites are important modulators. The gut microbiota and its metabolites can promote or inhibit the occurrence and development of CRC by affecting the host’s immune system， metabolic pathways， epigenetics， and signaling pathways. Therefore， the gut microbiota and its metabolites can serve as biomarkers for CRC， which can be used for CRC screening， diagnosis， staging， prognosis assessment， and treatment response monitoring. This review summarizes the currently discovered gut microbiota and its metabolites related to CRC， as well as their detection methods and clinical applications， evaluates the advantages， existing problems and prospects of CRC biomarkers based on gut microbiota and its metabolites， to provide a reference for the prevention and treatment of CRC. |
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