| 中文关键词: 乳腺癌 发病率 死亡率 年龄 疾病负担 女性 |
| 英文关键词:breast cancer incidence mortality age disease burden female |
| 基金项目:中国科协“一带一路”国际科技组织合作平台建设项目（2022ZN041102）；天津市医学重点学科（专科）建设项目（TJYXZDXK-009A) |
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| 中文摘要: |
| 摘 要：［目的］系统研究全球女性乳腺癌疾病负担现状。［方法］ 基于GLOBOCAN 2022发布的185个国家或地区女性乳腺癌的世界年龄标化发病率、标化死亡率和年龄特异发病率数据，分别按世界卫生组织（World Health Organization，WHO）地理区域和人类发展指数（human development index，HDI）水平两个维度进行分类，应用Graphpad Prism 8.3.0软件进行统计学分析并绘制小提琴图。［结果］ 6个WHO区域中，欧洲区域女性乳腺癌标化发病率（70.65/10万）最高，东地中海区域女性乳腺癌标化死亡率最高（18.07/10万）。超高HDI水平国家或地区女性乳腺癌标化发病率处于最高水平（71.90/10万），而中等HDI水平国家或地区女性乳腺癌标化死亡率处于较低（11.75/10万）水平。女性乳腺癌发病率随年龄增长呈上升趋势。WHO欧洲区域、超高和高HDI水平国家或地区的各年龄段女性乳腺癌年龄特异发病率均处于较高水平。五个乳腺癌新发病例数最多的国家中，中国、印度和巴西的女性乳腺癌发病的年龄结构主要集中在30～59岁，而美国和日本则在60岁以上。［结论］ 全球女性乳腺癌的疾病负担与地理分布和国家或地区社会经济发展水平有关。建议世界各国各地区要从顶层设计出发，综合考虑地理区域的特点和社会经济发展的因素，制定可持续的乳腺癌防控政策；面向全人群推广乳腺癌防治健康教育等。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the status quo of global burden of female breast cancer. ［Methods］ The data of age-standardized incidence rate(ASIR)， age-standardized mortality rate(ASMR) by world standard population and age-specific incidence of female breast cancer in 185 countries or regions released by GLOBOCAN 2022 were collected and analyzed by World Health Organization(WHO) geographical region and human development index(HDI) level. The Graphpad Prism 8.3.0 software was applied for statistical analysis and generating violin maps. ［Results］ In six WHO regions， the Europe region had the highest ASIR of female breast cancer (70.65/105)， the Eastern Mediterranean region had the highest ASMR (18.07/105). The ASIR of female breast cancer in countries or regions of very high HDI level was the highest (71.90/105)， while the ASMR in countries or regions of medium HDI levels were relatively low (11.75/105). The incidence of female breast cancer increased with age. The age-specific incidence of female breast cancer in women of all ages was high in the WHO Europe region， very high and high HDI level countries or regions. Of the five countries with the highest number of new cases of female breast cancer， the female breast cancer in China， India and Brazil， mainly occurred in the age groups of 30 to 59 years old， while that in United States and Japan mainly occurred after 60 years old. ［Conclusion］ The female breast cancer burden is associated with geographical region and national socioeconomic development level worldwide. It is suggested that countries and regions should formulate sustainable policies based on their geographical characteristics and socio-economic development level. |
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