| 邹雪平,杨千三,袁芝佩.2015—2019年四川省肿瘤登记地区食管癌流行特征与减寿年数变化趋势分析[J].中国肿瘤,2024,33(7):529-534. |
| 2015—2019年四川省肿瘤登记地区食管癌流行特征与减寿年数变化趋势分析 |
| Trend Analysis of Esophageal Cancer Epidemiologic Characteristics and Life Years Lost in Sichuan Cancer Registration Areas from 2015 to 2019 |
| 投稿时间：2024-03-02 |
| DOI：10.11735/j.issn.1004-0242.2024.07.A003 |
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| 中文关键词: 食管癌 发病率 死亡率 潜在减寿年数 四川 |
| 英文关键词:esophageal cancer incidence mortality potential years of life lost Sichuan |
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| 中文摘要: |
| 摘 要：［目的］ 分析2015—2019年四川省肿瘤登记地区食管癌的发病率、死亡率以及潜在寿命损失年的变化趋势。［方法］ 基于四川省各肿瘤登记处上报的2015—2019年间食管癌发病/死亡数据，以性别和年龄为分层依据，分别计算粗发病/死亡率和标化发病/死亡率。使用潜在减寿年数（potential years of life lost，PYLL）、平均潜在减寿年数（potential years of life lost，APYLL）和潜在减寿率（prospective life lost rate，PYLLR）等指标评估食管癌对人群生存与预期寿命的影响。利用Joinpoint软件计算年度变化百分比（percentage change，APC），分析2015—2019年变化趋势。［结果］ 2015—2019年四川省肿瘤登记地区食管癌的粗发病率为26.85/10万，其中男性的粗发病率（41.26/10万）高于女性（11.78/10万）；粗死亡率为20.74/10万，男性粗死亡率（32.09/10万）高于女性（8.86/10万）；无论男性、女性还是总体人群，标化发病率和死亡率均呈明显下降趋势（P均<0.05），标化发病率APC分别为-6.45%、-15.25%、-8.52%，标化死亡率APC分别为-5.63%、-11.77%、-6.94%。因食管癌死亡导致的总PYLL、APYLL和PYLLR分别为267 048人年、5.77人年和1.20‰。其中，APYLL和PYLLR均呈下降趋势（APC分别为-5.47%、-7.29%，P均<0.05），男性食管癌PYLL、APYLL和PYLLR均高于女性。［结论］ 2015—2019年四川省食管癌发病、死亡均呈下降趋势，男性和老年人是食管癌重点防治人群。 |
| 英文摘要: |
| Abstract：［Purpose］ To study the trend of incidence， mortality and potential life loss of esophageal cancer in cancer registration areas of Sichuan from 2015 to 2019. ［Methods］ The crude incidence and mortality rates， age-standardized rates based on age and sex stratification were estimated using the esophageal cancer incidence and mortality data from the Sichuan cancer registries from 2015 to 2019. The effect of esophageal cancer on population survival and life expectancy was assessed using potential years of life lost (PYLL)， average potential years of life lost (APYLL)， and prospective life lost rate (PYLLR). Use the Joinpoint software to calculate the annual percentage change (APC) and to analyze the trends of the incidence and mortality from 2015 to 2019. ［Results］ From 2015 to 2019， the crude incidence rate of esophageal cancer in Sichuan cancer registration areas was 26.85/105， with a higher rate among men (41.26/105) compared to women (11.78/105). The crude mortality rate was 20.74/105， with men having a higher rate (32.09/105) than women (8.86/105). The age-standardized incidence and mortality rates among men， women and whole population showed a significant decrease(all P<0.05)， with APC of -6.45%， -15.25%， and -8.52% for incidence rates， and -5.63%， -11.77%， and -6.94% for mortality rates， respectively. The overall PYLL， APYLL and PYLLR resulting from esophageal cancer fatalities were 267 048 person-years， 5.77 person-years and 1.20‰， respectively. Both APYLL and PYLLR exhibited a decrease (APC： -5.47% and -7.29%， respectively， both P<0.05). Men had higher levels of PYLL， APYLL and PYLLR for esophageal cancer compared to women. ［Conclusion］ The incidence and death rates of esophageal cancer in Sichuan Province decreased from 2015 to 2019， with men and the elderly being the primary target groups for prevention and treatment. |
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