陈永胜,王 军,张永辉,等.1972—2021年江苏省启东市胰腺癌发病流行趋势分析[J].中国肿瘤,2024,33(6):451-458.
1972—2021年江苏省启东市胰腺癌发病流行趋势分析
Trends of Pancreatic Cancer Incidence in Qidong City of Jiangsu Province from 1972 to 2021
投稿时间:2023-11-29  
DOI:10.11735/j.issn.1004-0242.2024.06.A005
中文关键词:  胰腺癌  发病率  流行特征  江苏
英文关键词:pancreatic cancer  incidence rate  epidemic characteristic  Jiangsu
基金项目:南通市“十四五”科教强卫工程(通卫科技〔2021〕15号);南通市卫生健康委员会科研课题(MS2023121,MSZ2023109)
作者单位
陈永胜 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
王 军 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
张永辉 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
丁璐璐 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
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中文摘要:
      摘 要:[目的] 分析启东市1972—2021年胰腺癌发病流行特征及变化趋势。[方法] 根据启东市1972—2021年胰腺癌发病登记数据和历年人口资料,计算粗发病率、中国人口标化发病率(中标率)、世界人口标化发病率(世标率)、35~64岁截缩率、0~74岁累积率和累积风险,应用 Joinpoint 4.9.1.0 统计软件分析胰腺癌发病率的年度变化百分比(APC)和平均年度变化百分比(AAPC);利用年龄-时期-队列模型分析年龄、时期和出生队列对胰腺癌发病趋势变化的影响。[结果] 1972—2021年启东市胰腺癌发病5 674例,占全部癌症发病的3.85%,粗发病率为10.12/10万,中标率为3.66/10万,世标率为6.09/10万,35~64岁截缩发病率为8.05/10万,0~74岁累积发病率为0.73%,累积风险为0.73%。男性发病3 122例,粗发病率、中标率、世标率分别为11.29/10万、4.47/10万、7.41/10万;女性发病2 552例,粗发病率、中标率、世标率分别为8.97/10万、2.93/10万、4.93/10万。0~44岁、45~54岁、55~64岁、65~74岁、75岁及以上组人群的发病率分别为0.63/10万、6.41/10万、19.06/10万、43.46/10万、68.24/10万,AAPC分别为1.30%(95%CI:-0.60%~3.23%)、1.12%(95%CI:0.10%~2.14%)、0.36%(95%CI:-0.70%~1.43%)、0.86%(95%CI:-0.16%~1.88%)、2.96%(95%CI:1.54%~4.41%)。其中,45~54岁、75岁及以上组的上升趋势有统计学意义(P均<0.05)。1972—2021年间胰腺癌粗发病率、中标率、世标率的AAPC分别为4.40%(95%CI:3.98%~4.81%)、0.95%(95%CI:0.57%~1.33%)、1.21%(95%CI:0.82%~1.59%),趋势均有统计学意义(P 均<0.001)。年龄-时期-队列模型分析显示,胰腺癌的发病风险随年龄的增长而升高,越晚出生的人发病风险越大(P均<0.05)。[结论] 启东市胰腺癌的发病率呈上升趋势,卫生行政部门应制定相应的防控措施,以降低胰腺癌负担。
英文摘要:
      Abstract: [Purpose] To analyze the trends of pancreatic cancer incidence in Qidong City of Jiangsu Province from 1972 to 2021. [Methods] The cancer registry data of pancreatic cancer incidence from 1972 to 2021 in Qidong were collected and analyzed. Crude rate (CR), age-standardi-zed rate by Chinese standard population and world standard population (ASRC and ASRW), annual percentage change (APC) and average annual percentage change(AAPC) were calculated. Age-period-cohort model was used to analyze the effects of age, period and birth cohort on the incidence trend of pancreatic cancer. [Results] From 1972 to 2021, there were 5 674 cases of pancreatic cancer reported in Qidong, accounting for 3.85% of all new cancer cases, with a CR of 10.12/105, ASRC of 3.66/105 and ASRW of 6.09/105. The truncated incidence of 35~64 years old was 8.05/105, the cumulative incidence rate of 0~74 years old was 0.73%, and the cumulative risk was 0.73%. There were 3 122 male cases and 2 552 female cases; the CR, ASRC, ASRW of males and females were 11.29/105, 4.47/105, 7.41/105 and 8.97/105, 2.93/105, 4.93/105, respectively. The CR of the age groups of 0~44, 45~54, 55~64, 65~74, ≥75 years old were 0.63/105, 6.41/105, 19.06/105, 43.46/105, 68.24/105, respectively; and the corresponding AAPCs were 1.30% (95%CI: -0.60%~3.23%, P>0.05), 1.12% (95%CI: 0.10%~2.14%, P<0.05), 0.36% (95%CI: -0.70%~1.43%, P>0.05), 0.86% (95%CI: -0.16%~1.88%, P>0.05), 2.96% (95%CI: 1.54%~4.41%, P<0.05). From 1972 to 2021, the AAPCs of CR, ASRC and ASRW of pancreatic cancer were 4.40% (95%CI: 3.98%~4.81%, P<0.05), 0.95% (95%CI: 0.57%~1.33%, P<0.05), 1.21% (95%CI: 0.82%~1.59%, P<0.05). The age-period-cohort model showed that the risk of pancreatic cancer increased with age, and the risk of pancreatic cancer was positively correlated with the birth cohort (P<0.05). [Conclusion] The incidence of pancreatic cancer has presented a rising trend in Qidong City of Jiangsu Province over the last fifty years. The health authorities should formulate prevention and control measures to reduce the burden of pancreatic cancer.
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