| 张颖婕,刘佩意,王 贺,等.宫颈癌免费筛查女性生殖道沙眼衣原体感染与高危型人乳头瘤病毒感染的关联性研究[J].中国肿瘤,2024,33(4):334-340. |
| 宫颈癌免费筛查女性生殖道沙眼衣原体感染与高危型人乳头瘤病毒感染的关联性研究 |
| Association Between Genital Chlamydia Trachomatis Infection and High-Risk Human Papillomavirus Infection Among Women Undergoing Cervical Cancer Screening |
| 投稿时间：2024-01-08 |
| DOI：10.11735/j.issn.1004-0242.2024.04.A011 |
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| 中文关键词: 高危型人乳头瘤病毒 沙眼衣原体 宫颈癌 影响因素 |
| 英文关键词:high-risk human papillomavirus chlamydia trachomatis cervical cancer influential factor |
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| 中文摘要: |
| 摘 要：［目的］ 分析宫颈癌免费筛查女性中生殖道沙眼衣原体（GCT）感染与高危型人乳头瘤病毒（HR-HPV）感染的关联性。［方法］ 采用横断面研究设计，选取2021年11月至2022年5月期间于深圳市罗湖区妇幼保健院参加宫颈癌免费筛查的1 494名健康女性为研究对象，通过问卷调查收集研究对象的人口学资料、生活习惯、性行为史及生殖生育史。采用Logistic回归模型分析女性GCT感染与HR-HPV感染的关联性。［结果］ GCT的阳性率为4.4%，HR-HPV的阳性率为11.0%。其中，GCT阳性组的女性HR-HPV阳性率（25.8%）高于阴性组（10.4%）（P<0.001）。多因素Logistic回归模型结果显示，在校正人口学资料、生活习惯、性行为史和生殖生育史后，GCT感染与HR-HPV感染存在显著关联（OR=2.80，95%CI：1.51~5.19）。［结论］ 女性GCT感染与HR-HPV感染有显著关联性，GCT感染的女性HR-HPV感染的可能性更大，应加强对这部分人群的预防保健、早期筛查和及时干预工作。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the association between genital chlamydia trachomatis(GCT) infection and high-risk human papillomavirus (HR-HPV) infection among women undergoing cervical cancer screening. ［Methods］ A total of 1 494 women undergoing cervical cancer screening in Shenzhen Luohu Maternity and Child Health Hospital from November 2021 to May 2022 were enrolled. A self-designed questionnaire was used to collect baseline data of participants， including demographic data， lifestyle habits， sexual behavior and reproductive history. Logistic regression models were used to examine the association between GCT infection and HR-HPV infection. ［Results］ The positive infection rates of GCT and HR-HPV were 4.4% and 11.0%， respectively. The HR-HPV positive rate in the GCT infection group was significantly higher than that in the non-infection group (25.8% vs 10.4%， P<0.001). Multivariate Logistic regression model results demonstrated that after adjusting for demographic data， lifestyle habits， sexual behavior history and reproductive history， GCT infection was significantly associated with HR-HPV infection (OR=2.80， 95%CI：1.51~5.19). ［Conclusion］ There is a significant association between female GCT infection and HR-HPV infection， indicating that for women with GCT infection it is necessary to strengthen preventive measures to prevent HR-HPV infection. |
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