| 蒋成英,李佳珍,郭晓静.铁死亡在乳腺癌肿瘤耐药中的研究进展[J].中国肿瘤,2024,33(4):326-333. |
| 铁死亡在乳腺癌肿瘤耐药中的研究进展 |
| Research Progress on Roles of Ferroptosis in Chemotherapy Resistance of Breast Cancer |
| 投稿时间：2023-07-09 |
| DOI：10.11735/j.issn.1004-0242.2024.04.A010 |
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| 中文关键词: 铁死亡 乳腺癌 化疗耐药 铁代谢 |
| 英文关键词:ferroptosis breast cancer chemotherapy resistance iron metabolism |
| 基金项目:国家自然科学基金（81772840） |
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| 摘要点击次数: 47 |
| 全文下载次数: 25 |
| 中文摘要: |
| 摘 要：乳腺癌是女性最常见的恶性肿瘤，肿瘤耐药是制约乳腺癌临床疗效的瓶颈，克服其肿瘤耐药性是亟待解决的问题。铁死亡是一种新型以铁依赖性脂质活性氧堆积为特征的细胞死亡，在乳腺癌及其耐药中具有重要作用。全文对铁死亡在乳腺癌耐药中的作用及其研究进展进行综述。通过评估铁死亡诱导剂、抑制剂及调节铁死亡通路在肿瘤耐药中作用，期待针对铁死亡通路的生物治疗将来成为逆转肿瘤耐药的治疗策略，为乳腺癌患者带来福音。 |
| 英文摘要: |
| Abstract： Breast cancer is the most common malignant tumor for women， chemotherapy resistance become a bottleneck for the clinical treatment. Ferroptosis is a newly discovered form of programmed cell death characterized by iron-dependent accumulation of lipid reactive oxygen species， and it plays an important role in breast cancer and its chemotherapy resistance. This paper reviews the research progress of ferroptosis in breast cancer， focusing on ferroptotic inducers and ferroptotic inhibitors， and their roles in modulating ferroptosis in chemotherapy resistance of breast cancer. It is expected that the biotherapy targeting the ferroptosis pathway would be a novel strategy to reverse chemotherapy resistance for breast cancer patients in the future. |
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