林 玲,韩亚蓉,韩颖颖,等.2006—2020年江苏省南通市肝癌死亡趋势的年龄-时期-队列分析[J].中国肿瘤,2024,33(3):180-185. |
2006—2020年江苏省南通市肝癌死亡趋势的年龄-时期-队列分析 |
Analysis on the Trend of Liver Cancer Mortality Based on Age-Period-Cohort Model in Nantong of Jiangsu from 2006 to 2020 |
投稿时间:2023-11-16 |
DOI:10.11735/j.issn.1004-0242.2024.03.A003 |
|
 |
中文关键词: 肝癌 死亡率 年龄-时期-队列模型 江苏 |
英文关键词:liver cancer mortality age-period-cohort model Jiangsu |
基金项目:中国乙肝防控科研基金(YGFK20210063);南通市卫生健康委员会科研课题(QNZ2023083) |
|
摘要点击次数: 514 |
全文下载次数: 264 |
中文摘要: |
摘 要:[目的] 探讨2006—2020年江苏省南通市人群肝癌死亡趋势及年龄、时期、队列对死亡风险的影响。[方法] 基于南通市肿瘤登记数据库中因肝癌死亡的数据,采用Joinpoint回归模型分析2006—2020年江苏省南通市人群肝癌死亡变化趋势,采用年龄-时期-队列模型分析南通市肝癌死亡风险的年龄、时期和队列效应。[结果] 2006—2020年,南通市肝癌粗死亡率和标化死亡率均呈下降趋势(粗死亡率AAPC=-3.61%,95%CI:-4.10%~-3.11%;标化死亡率AAPC=-7.48%,95%CI:-8.21%~-6.74%)。年龄-时期-队列模型分析结果显示,2006—2020年江苏省南通市人群肝癌死亡率的年龄效应总体上随年龄的增长呈先升后降的趋势,死亡风险从20岁开始逐渐升高,40~44岁达到高峰。时期效应显示,随着时间的推移,肝癌死亡风险逐渐下降,2006—2010年肝癌死亡相对危险度(RR)为2011—2015年的1.54倍(RR=1.54,95%CI:1.43~1.66),而2016—2020年比2011—2015年低38%(RR=0.62,95%CI:0.58~0.67)。队列效应显示,出生年代越晚,肝癌死亡风险越低。死亡风险从1926—1930年(RR=9.52,95%CI:7.48~12.18)至1996—2000年队列(RR=0.01,95%CI:0.00~0.20)逐渐降低。[结论] 2006—2020年江苏省南通市人群肝癌死亡率呈逐渐下降趋势。肝癌死亡风险随着年龄的增长呈现先上升后下降的趋势,越晚出生的人死亡风险越低。建议将中年劳动力人群作为肝癌重点防控对象。 |
英文摘要: |
Abstract:[Purpose] To analyze the trends of liver cancer mortality among residents in Nantong of Jiangsu from 2006 to 2020 based on age-period-cohort model. [Methods] The liver cancer morta-lity data from 2006 to 2020 were collected from the Nantong Cancer Registration Database. The trends of liver cancer death were analyzed with Joinpoint regression model; and the effects of age, period and cohort on the risk of liver cancer mortality were analyzed with the age-period-cohort model. [Results] From 2006 to 2020, both the crude and age-standardized mortality rates of liver cancer in Nantong showed a downward trend with AAPC of crude mortality rate of -3.61% (95%CI: -4.10%~-3.11%) and standard mortality rate of -7.48% (95%CI: -8.21%~-6.74%). The results of age-period-cohort model analysis showed that the mortality risk increased from the age of 20 and reached its peak at the age of 40~44. The relative risk (RR) of liver cancer death from 2006 to 2010 was 1.54 times that of 2011—2015 (RR=1.54, 95%CI: 1.43~1.66), with 38% lower from 2016 to 2020 than that from 2011 to 2015 (RR=0.62, 95%CI: 0.58~0.67). The mortality risk decreased gradually from the birth cohort of 1926—1930 (RR=9.52, 95%CI:7.48~12.18) to 1996—2000 cohort (RR=0.01, 95%CI: 0.00~0.20). [Conclusion] From 2006 to 2020, the mortality rate of liver cancer in Nantong of Jiangsu Province showed a gradual decline. The risk of death from liver cancer increases first and then decreases with age, and the people with later time of birth have the lower risk of liver cancer death. The middle-age labor force should be focused on for liver cancer prevention and control. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |