| 刘晓轩,张 驰,黄思琪,等.SLC7A11的调控机制及肿瘤治疗应用研究进展[J].中国肿瘤,2023,32(11):878-885. |
| SLC7A11的调控机制及肿瘤治疗应用研究进展 |
| Regulatory Mechanism of SLC7A11 and Its Applications in Cancer Treatment |
| 投稿时间：2023-05-14 |
| DOI：10.11735/j.issn.1004-0242.2023.11.A010 |
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| 中文关键词: 逆向转运蛋白 溶质载体家族7成员11 氧化应激 铁死亡 调控机制 肿瘤治疗 |
| 英文关键词:reverse transporter protein SLC7A11 oxidative stress ferroptosis regulatory mechanism tumor therapy |
| 基金项目: |
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| 中文摘要: |
| 摘 要：胱氨酸/谷氨酸逆向转运蛋白 SLC7A11（也称为 xCT）可介导细胞外胱氨酸的摄取以换取谷氨酸。胱氨酸被还原为谷胱甘肽合成的限速前体半胱氨酸，这一过程保护细胞免受氧化应激，因此对细胞生长、增殖和新陈代谢至关重要。由于SLC7A11的特殊结构功能，其参与到了铁死亡的启动过程中。因此，SLC7A11可能成为临床治疗癌症的潜在靶点。目前已有研究通过各种SLC7A11调节剂来调节SLC7A11的表达或活性以实现对铁死亡的调节，从而影响肿瘤微环境、免疫逃逸、肿瘤进程、化疗耐药以及肿瘤靶向治疗。全文就SLC7A11的调控机制及肿瘤治疗应用做一综述，以期为肿瘤治疗提供新思路。 |
| 英文摘要: |
| Abstract： The cystine/glutamate transporter SLC7A11 (also known as xCT) mediates the uptake of extracellular cystine in exchange for glutamate. Cysteine reduced from cystine is a rate-limiting precursor of glutathione synthesis， which protects cells from oxidative stress and is therefore essential for cell growth， proliferation and metabolism. SLC7A11 is involved in the initiation of ferroptosis due to its specific structure and function. Studies have shown that the expression or activity of SLC7A11 can be regulated by various SLC7A11 modulators to induce cell ferroptosis， affecting tumor microenvironment， immune escape， tumour progression and chemotherapy resistance， indicating that SLC7A11 may be a potential target for treatment of malignant tumors. This paper reviews the regulatory mechanisms of SLC7A11 and its potential application in tumor therapy. |
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