| 寻鲁宁,王 冲,沈成凤,等.2010—2016年天津市结直肠癌发病及生存分析[J].中国肿瘤,2023,32(9):661-668. |
| 2010—2016年天津市结直肠癌发病及生存分析 |
| Incidence and Survival of Colorectal Cancer in Tianjin from 2010 to 2016 |
| 投稿时间：2023-06-19 |
| DOI：10.11735/j.issn.1004-0242.2023.09.A003 |
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| 中文关键词: 结直肠癌 发病率 观察生存率 相对生存率 趋势 天津 |
| 英文关键词:colorectal cancer incidence overall survival rate relative survival rate trend Tianjin |
| 基金项目:天津市卫生高层次人才选拔培养项目（津人才［2018］19号）；天津市医学重点学科（专科）建设项目（TJYXZDXK-051A） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2010—2016年天津市结直肠癌发病及5年生存情况。［方法］ 收集2010—2016年天津市结直肠癌发病资料，随访截止日期为2021年12月31日。使用SPSS 24.0和R 4.1.2软件进行统计分析，计算结直肠癌粗发病率和标化发病率，应用寿命表法计算观察生存率，EdererⅡ法计算相对生存率。采用Joinpoint回归模型计算2010—2016年天津市结直肠癌发病和生存率平均年度变化百分比（average annual percentage change，AAPC），分析其变化趋势。［结果］ 2010—2016年天津市共报告结直肠癌发病数18 771例，粗发病率为26.66/10万，中标发病率为14.34/10万。男性发病率高于女性，城市地区高于农村。结直肠癌年龄别发病率在44岁之前处于较低水平，45岁以后随着年龄的增长快速上升，到80~84岁年龄组到达最高峰。全人群发病率呈现逐年上升趋势（AAPC=6.69%，P=0.020），男性年均增速高于女性，农村地区高于城市。2010—2016年天津市结直肠癌5年观察生存率为47.39%，相对生存率为55.03%，女性5年观察生存率高于男性，农村地区高于城市，65岁及以上人群5年观察生存率较低。全人群5年观察生存率呈现逐年递增趋势（AAPC=2.80%，P=0.030）。［结论］ 2010—2016年天津市结直肠癌发病仍处于较高水平，且呈现逐年上升趋势。全人群结直肠癌5年生存率逐年提高，65岁及以上老年人群生存率相对较低。需针对重点人群做好防控措施，有效降低结直肠癌发病率，提高患者生存水平。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence of colorectal cancer and 5-year survival of patients in Tianjin from 2010 to 2016. ［Methods］ The data of colorectal cancer in Tianjin from 2010 to 2016 were collected and patients were followed-up till 31 December， 2021. SPSS 24.0 and R 4.1.2 softwares were used for statistical analysis. The crude rates of incidence and age-standardized incidence rate(ASIR) were calculated. The overall survival rate(OSR) and relative survival rate (RSR) were calculated by the Life-table program and EdererⅡmethod. Joinpoint regression model was used to analyze the average annual percentage changes(AAPC) of the incidence and survival from 2010 to 2016. ［Results］ A total of 18 771 cases of colorectal cancer were reported in Tianjin from 2010 to 2016. The crude incidence rate of colorectal cancer was 26.66/105， the age-standardized incidence rate by Chinese standard population (ASIRC) was 14.34/105. The incidence rate of colorectal cancer in male was higher than that in female， and was higher in urban areas than that in rural areas. The incidence rate of colorectal cancer was at a low level in the age of 0~44 years old， and increased rapidly after the age of 45 years old， reaching the highest in the age group of 80~84 years old. The incidence rate of colorectal cancer showed an increasing trend for whole population(AAPC=6.69%， P=0.020). The trend in male was higher than that in female， and was higher in rural areas than that in urban areas. The 5-year OSR from 2010 to 2016 was 47.39% and the 5-year RSR was 55.03%. The 5-year OSR in female was higher than that in male， and was higher in rural areas than that in urban areas. The 5-year OSR was lower in the age group of 65~ years old. The 5-year OSR showed an increasing trend for whole population (AAPC=2.80%， P=0.030). ［Conclusion］ From 2010 to 2016， the incidence rate of colorectal cancer in Tianjin remained a high level and showed an rising trend year by year. The 5-year OSR increased gradually for whole popu-lation， while the OSR in the age group of 65~ years old was relatively low. Prevention and control measures should be taken for key populations to reduce the incidence rate of colorectal cancer and improve the survival level of patients. |
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