| 湛世承,杨敏生,苏石汉,等.2014—2018年广西苍梧县鼻咽癌疾病负担及其变化趋势分析[J].中国肿瘤,2023,32(5):360-367. |
| 2014—2018年广西苍梧县鼻咽癌疾病负担及其变化趋势分析 |
| Trend of Disease Burden on Nasopharyngeal Carcinoma in Cangwu County of Guangxi from 2014 to 2018 |
| 投稿时间：2022-09-30 |
| DOI：10.11735/j.issn.1004-0242.2023.05.A005 |
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| 中文关键词: 鼻咽癌 疾病负担 发病率 死亡率 伤残调整寿命年 广西 |
| 英文关键词:nasopharyngeal carcinoma disease burden incidence mortality disability-adjusted life years Guangxi |
| 基金项目:广西重点研发计划（桂科AA18221001，桂科AB18050020）；国家自然科学基金地区科学基金项目（82060431）；广西自然科学基金（2020GXNSFAA259022）；广西卫健委肿瘤分子医学重点（培育）实验室（ZPTJ2020001） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2014—2018年广西苍梧县鼻咽癌疾病负担水平及变化趋势。［方法］ 根据苍梧县肿瘤登记处上报的2014—2018年鼻咽癌发病和死亡数据，计算粗发病率和死亡率及其标化率、过早死亡损失寿命年（years of life lost，YLLs）、伤残损失寿命年（years lived with disability，YLDs）和伤残调整寿命年（disability-adjusted life years，DALYs）等指标。通过Joinpoint回归模型计算鼻咽癌发病率、死亡率及DALYs率的平均年度变化百分比（average annual percentage change，AAPC）并分析其变化趋势。 ［结果］ 2014—2018年广西苍梧县累计报告鼻咽癌发病数599例（包括男性453例和女性146例），死亡数304例（包括男性237例和女性67例）。2014—2018年广西苍梧县因鼻咽癌损失的DALYs为5 386.47人年，其中YLLs和YLDs分别占92.99%和7.01%。2014—2018年鼻咽癌发病率（AAPC=-5.3%）、死亡率（AAPC=-11.6%）和DALYs率（AAPC=-7.6%）总体呈下降趋势，但变化趋势无统计学意义（P>0.05）。不同性别的发病率、死亡率和DALYs率变化趋势与总体趋势基本一致，其中女性鼻咽癌的死亡率和DALYs率呈显著下降趋势：女性鼻咽癌死亡率由2014年的11.14/10万下降至2018年的4.19/10万，年均下降21.4%（P<0.01）；DALYs率由2014年的180.15/10万人年下降至2018年的66.49/10万人年，年均下降23.3%（P<0.01）。［结论］ 2014—2018年广西苍梧县居民鼻咽癌的发病率、死亡率和DALYs率均有所下降，尤其女性鼻咽癌的疾病负担呈明显下降趋势。但鼻咽癌仍是苍梧县需要重点防控的区域性高发肿瘤，今后还需加强鼻咽癌的早诊早治和筛查工作，针对高危人群采取积极的干预措施，降低鼻咽癌的疾病负担。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the disease burden of nasopharyngeal carcinoma(NPC) and its trends from 2014 to 2018 in Cangwu County of Guangxi. ［Methods］The data of new NPC cases and deaths were collected from Cangwu Cancer Registry， and the crude incidence/mortality rates， age-standardized incidence/mortality rates(ASR)， years lived with disability(YLDs)， years of life lost(YLLs) and disability-adjusted life years(DALYs) were calculated . Trends of incidence， mortality and DALYs rates of NPC were estimated by the Joinpoint model and characterized by average annual percentage change(AAPC). ［Results］ From 2014 to 2018， a total of 599 NPC cases(male： 453， female： 146) and 304 NPC deaths(male： 237， female： 67) were reported in Cangwu County. From 2014 to 2018， the overall DALYs of NPC were 5 386.47 person years， of which YLDs and YLLs accounted for 92.99% and 7.01%， respectively. The AAPC of incidence， mortality and DALYs rates were -5.3%， -11.6% and -7.6% from 2014 to 2018， respectively(P>0.05). The trends of incidence， mortality and DALYs rate in male and in female were basically consistent with the overall trends， in which the rates of mortality and DALYs among females showed a significant downward trend. The mortality rate among females decreased by 21.4% on average per year from 11.14/105 in 2014 to 4.19/105 in 2018(P<0.01) and the DALYs rates among females decreased by 23.3% on average per year from 180.15/105 person-year in 2014 to 66.49/105 person-year in 2018(P<0.01). ［Conclusion］ From 2014 to 2018， the rates of incidence， mortality and DALYs of NPC in Cangwu County shows a decreasing trend， in particular， the disease burden of NPC among females decreased significantly. But NPC is still a regional high-incidence cancer in Cangwu， the prevention and control measures should be further strengthened. |
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