| 韩喜婷,孙长青,程亮星,等.1990—2019年中国卵巢癌疾病负担及其变化趋势分析[J].中国肿瘤,2023,32(5):333-338. |
| 1990—2019年中国卵巢癌疾病负担及其变化趋势分析 |
| Disease Burden and Its Trends of Ovarian Cancer in China from 1990 to 2019 |
| 投稿时间：2022-12-07 |
| DOI：10.11735/j.issn.1004-0242.2023.05.A002 |
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| 中文关键词: 卵巢癌 发病率 死亡率 疾病负担 中国 |
| 英文关键词:ovarian cancer incidence mortality disease burden China |
| 基金项目:河南省医学科技攻关计划联合共建项目(LHGJ20210374)；国家社会科学基金项目(20BRK041) |
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| 中文摘要: |
| 摘 要：［目的］ 分析1990—2019年中国卵巢癌疾病负担长期变化趋势。［方法］ 通过全球疾病负担研究（GBD）数据，应用Joinpoint 4.9.1.0软件分析1990—2019年中国卵巢癌标化患病率、发病率、死亡率、伤残调整寿命年（DALYs）、过早死亡损失寿命年（YLLs）和伤残损失寿命年（YLDs）等指标的平均年度变化百分比（AAPC）。［结果］ 1990—2019年中国卵巢癌的患病数、发病数和死亡数均有明显增加。标化患病率从10.11/10万增加至20.44/10万，标化发病率从2.56/10万增加至4.54/10万，标化死亡率从1.76/10万增加至2.77/10万，标化DALYs率从55.57/10万增加至80.52/10万。标化患病率、标化发病率、标化死亡率、标化DALYs率、标化YLLs率和标化YLDs率整体均呈上升趋势，AAPC值分别为2.48%、2.02%、1.58%、1.32%、1.32%和2.26%，差异均具有统计学意义（P<0.001）。从35岁开始卵巢癌疾病负担快速上升，发病率和DALYs率在65~69岁组最高，死亡率在≥70岁组最高。［结论］ 1990—2019年中国卵巢癌疾病负担有明显上升趋势，且老年人增加更为明显，应尽快完善三级预防策略，加强女性生殖系统的健康宣教，以有效减少卵巢癌的发病和死亡。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the trends of disease burden of ovarian cancer in China from 1990 to 2019. ［Methods］ Based on the Global Burden of Disease(GBD) Study， the Joinpoint 4.9.1.0 software was used to analyze the average annual percentage change(AAPC) of standardized prevalence rate， standardized incidence rate， standardized mortality rate， standardized disability-adjusted life years(DALYs) rate， standardized years of life lost(YLLs）and standardized years lived with disability(YLDs）rate of ovarian cancer in China from 1990 to 2019. ［Results］ From 1990 to 2019， the standardized prevalence rate increased from 10.11/105 to 20.44/105， the standardized incidence rate from 2.56/105 to 4.54/105， the mortality rate from 1.76/105 to 2.77/105， and the DALYs rate from 55.57/105 to 80.52/105 in China. The standardized prevalence rate(AAPC=2.48%)， standardized incidence rate(AAPC=2.02%)， standardized mortality rate(AAPC=1.58%)， standardized DALYs rate(AAPC=1.32%)， standardized YLLs rate(AAPC=1.32%) and standardized YLDs rate(AAPC=2.26%) showed an upward trend(P<0.001). The disease burden of ovarian cancer increased rapidly after the age of 35. The incidence and DALYs rates at the age group of 65~69 years were the highest， and the mortality rate at the age group of 70 years and older was the highest among all age groups. ［Conclusion］ From 1990 to 2019， the disease burden of ovarian cancer in China shows an upward trend， particularly in the elderly population. The three-tier prevention strategy should be strengthened to reduce the incidence and mortality of ovarian cancer. |
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