| 陈莉莉,丁高恒,袁浩冉,等.2018 年甘肃省肿瘤登记地区女性乳腺癌流行特征及 2010—2018 年变化趋势[J].中国肿瘤,2022,31(12):1001-1007. |
| 2018 年甘肃省肿瘤登记地区女性乳腺癌流行特征及 2010—2018 年变化趋势 |
| Incidence and Mortality of Female Breast Cancer in Gansu Cancer Registration Areas in 2018 and the Trends from 2010 to 2018 |
| 投稿时间：2022-05-27 |
| DOI：10.11735/j.issn.1004-0242.2022.12.A009 |
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| 中文关键词: 乳腺癌 女性 发病率 死亡率 变化趋势 甘肃 |
| 英文关键词:breast cancer female incidence mortality trend Gansu |
| 基金项目:兰州市科技指导项目(2019-ZD-133)；兰州市科技计划项目（2018-1-122） |
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| 中文摘要: |
| 摘 要：［目的］ 分析 2018 年甘肃省女性乳腺癌的流行情况及 2010—2018 年期间甘肃省女性乳腺癌的流行趋势。［方法］ 收集2021年甘肃省23个肿瘤登记点上报的恶性肿瘤发病、死亡及人口资料登记数据，其中15个登记点数据符合质量控制标准。按城乡和年龄组分层计算发病（死亡）率、中国人口标化率（中标率）、世界人口标化率（世标率）和累积发病（死亡）率（0~74岁）等指标。利用Joinpoint线性回归模型计算2010—2018年甘肃省女性乳腺癌发病率、死亡率的年度变化百分比（APC）。［结果］ 2018 年甘肃省肿瘤登记地区女性乳腺癌位居女性癌症发病谱第1位，新发病例为822例，占全部女性恶性肿瘤发病的 14.03%，发病率为 31.37/10万，中标发病率为24.39/10万，世标发病率为24.00/10万，累积发病率（0~74岁）为2.37%。城市和农村地区的乳腺癌中标发病率分别为23.23/10万和25.81/10万。甘肃省肿瘤登记地区女性乳腺癌死亡位居女性恶性肿瘤死亡谱第5位，死亡病例为161例，占全部女性恶性肿瘤死亡的6.17%，死亡率为6.14/10万，中标死亡率为4.53/10万，世标死亡率为4.81/10万，累积死亡率（0~74岁）为0.50%。城市和农村地区乳腺癌中标死亡率分别为3.82/10万和5.29/10万。2010—2018年期间，甘肃省女性乳腺癌粗发病率和死亡率变化均无统计学意义（粗发病率：APC=1.46%，P=0.43；粗死亡率：APC=-5.82%，P=0.22），标化发病率和死亡率变化也无统计学意义（标化发病率：APC=-0.50%，P=0.80；标化死亡率：APC=-7.00%，P=0.20）。［结论］ 2018年甘肃省女性乳腺癌发病和死亡水平低于全国平均水平，但防控形势依然严峻，应针对女性乳腺癌的流行特征特点进一步加强乳腺癌的防治工作。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and mortality of female breast cancer in Gansu cancer registration areas in 2018 and its trend of changes during 2010—2018. ［Methods］ The data of cancer incidence， mortality and population data reported by 23 cancer registries in Gansu Province in 2021 were collected， and the data from 15 registries met the quality control standards. The incidence and mortality， standardized rate by Chinese standard population in 2000(ASIRC， ASMRC) and Segi’s population(ASIRW， ASMRW) ， cumulative rate(0~74 years old) of female breast cancer were calculated by the areas(urban and rural) and age groups. Joinpoint software was used to calculate the annual percentage change(APC)． [Results］ The female breast cancer was the most common cancer among females in the cancer registration areas of Gansu Province in 2018， there were 822 new cases of female breast cancer， accounting for 14.03% of all new cancer cases among females. The crude incidence rate was 31.37/105. The ASIRC and ASIRW were 24.39/105 and 24.00/105， respectively. The cumulative incidence rate(0~74 years old) was 2.37%. The ASIRC in urban and rural areas was 23.23/105 and 25.81/105， respectively. The female breast cancer was the fifth most common cause of cancer deaths among females， 161 women died of breast cancer， accounting for 6.17% of all cancers deaths among females. The crude mortality of female breast cancer was 6.14/105， the ASMRC and ASMRW were 4.53/105 and 4.81/105， respectively. The cumulative mortality rate(0~74 years old) was 0.50%. The ASMRC in urban and rural areas was 3.82/105 and 5.29/105， respectively. There was no significant change in crude incidence rate(APC=1.46%， P=0.43) and crude mortality rate(APC=-5.82%， P=0.22) of female breast cancer from 2010 to 2018； and also no significant change in age-standardized incidence(APC= -0.50%， P=0.80) and mortality rates(APC=-7.00%， P=0.20) . ［Conclusion］ In 2018， the incidence and mortality of female breast cancer in Gansu Province were lower than the national average， there were no significant change of breast cancer incidence and mortality from 2010 to 2018． |
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