张丹眉,石春霞,龚作炯.肝细胞癌中表观遗传改变对免疫治疗的影响[J].中国肿瘤,2022,31(11):929-935.
肝细胞癌中表观遗传改变对免疫治疗的影响
Effects of Epigenetic Changes on Immunotherapy in Hepatocellular Carcinoma
投稿时间:2022-03-31  
DOI:10.11735/j.issn.1004-0242.2022.11.A013
中文关键词:  肝细胞癌  表观遗传  免疫治疗  联合治疗  肿瘤免疫
英文关键词:hepatocellular carcinoma  epigenetics  immunotherapy  combination therapy  tumor immunity
基金项目:国家自然科学基金(82070609)
作者单位
张丹眉 武汉大学人民医院 
石春霞 武汉大学人民医院 
龚作炯 武汉大学人民医院 
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中文摘要:
      摘 要:肝细胞癌是最常见的恶性肿瘤之一,早期诊断困难,致死率高,相对于其他恶性肿瘤而言欠缺有效的治疗方法。近年来,表观遗传机制被广泛研究,与基因突变不同,表观遗传改变是动态的、可靶向修正的,且表观遗传失调对肿瘤免疫也产生影响。靶向修正表观遗传能够改善肿瘤免疫,增强免疫治疗效果,为探索新型联合治疗带来希望。全文主要讨论肝细胞癌发生发展过程中表观遗传的主要变化以及表观遗传对肿瘤免疫的影响,探索联合靶向表观遗传和免疫治疗新疗法。
英文摘要:
      Abstract: Hepatocellular carcinoma(HCC) is one of the most common malignant tumors. It is difficult to diagnose at the early stage and has a high mortality rate and lack of effective treatment methods compared with other malignant tumors. In recent years, epigenetic mechanisms have been extensively studied. Unlike gene mutations, epigenetic changes are dynamic and targetable, and epigenetic dysregulation also affects tumor immunity. Targeted modification of epigenetics can improve tumor immunity and enhance the effects of immunotherapy, bringing hope for the exploration of new combination therapies. This article reviews the main changes of epigenetics during the occurrence and development of HCC and the impact of epigenetics on tumor immunity, and explores new therapies that combine targeting epigenetics and immunotherapy.
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