| 张 辉,张 爽,郑文龙,等.1999—2018年天津市胆囊及胆道其他恶性肿瘤死亡流行特征分析[J].中国肿瘤,2022,31(8):632-638. |
| 1999—2018年天津市胆囊及胆道其他恶性肿瘤死亡流行特征分析 |
| Analysis on Trend of Gallbladder and Biliary Tract Cancer Mortality from 1999 to 2018 in Tianjin City |
| 投稿时间：2021-12-03 |
| DOI：10.11735/j.issn.1004-0242.2022.08.A003 |
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| 中文关键词: 胆囊及胆道其他恶性肿瘤 肿瘤登记 死亡率 天津 |
| 英文关键词:gallbladder and biliary tract cancer cancer registration mortality Tianjin |
| 基金项目:天津市医学重点学科（专科）建设项目资助（津卫科教〔2021〕492号） |
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| 中文摘要: |
| 摘 要：［目的］ 分析天津市居民1999—2018年胆囊及胆道其他恶性肿瘤死亡率水平及其变化趋势。［方法］ 采用天津市疾病预防控制中心收集的居民全死因监测数据，统计1999—2018年天津市居民胆囊及胆道其他恶性肿瘤死亡水平，计算其死亡数、死亡率（包括粗死亡率和经年龄调整后的标化死亡率）。分析其20年间的变化趋势以及在城乡、不同性别、不同年龄之间分布的差异。 ［结果］ 1999—2018年期间，天津市胆囊及胆道其他恶性肿瘤死亡5 055例，粗死亡率从0.94/10 万上升到4.41/10万（t=14.23，P<0.001），标化死亡率从0.73/10万上升至2.01/10万，呈显著上升趋势（t=8.07，P<0.001）。死亡年龄中位数历年来无明显变化（P>0.05），在70岁左右。历年来，45岁以前胆囊及胆道其他恶性肿瘤死亡率均处于较低水平且无明显变化（P>0.05），45岁及以上人群死亡率开始增加，并随年龄增大而增长，65岁及以上组呈现显著上升趋势（P<0.01）。胆囊及胆道其他恶性肿瘤男性标化死亡率从1999年的0.79/10万上升至2018年的2.21/10万（APC=4.19%，t=9.05，P<0.001），女性标化死亡率从1999年的0.68/10万上升至2018年的1.82/10万（APC=3.57%，t=5.89，P<0.001）；城市地区标化死亡率从1999年的1.05/10万上升至2018年的2.09/10万，农村地区则从1999年的0.31/10万上升至2018年的1.87/10万，且农村标化死亡率上升速度更快（城市：APC=2.19%，t=3.78，P<0.001；农村：APC=8.06%，t=13.58，P<0.001）。［结论］ 1999—2018年天津市居民胆囊及胆道其他恶性肿瘤粗死亡率及标化死亡率明显上升，65岁及以上老年人、城市居民为胆囊及胆道其他恶性肿瘤死亡高发人群，不同性别之间胆囊及胆道其他恶性肿瘤死亡无明显差异。应采取针对性的防治措施，降低胆囊及胆道其他恶性肿瘤的死亡率。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the mortality and trend of gallbladder and biliary tract cancer among residents from 1999 to 2018 in Tianjin City. ［Methods］ The data of all causes of death were collected by Tianjin Center for Disease Control and Prevention. The death number， crude mortality rate and standardized mortality rate of gallbladder and biliary tract cancer from 1999 to 2018 in Tianjin City were calculated. The trends of gallbladder and biliary tract cancer from 1999 to 2018 were calculated by area(urban and rural)， gender and age. ［Results］ From 1999 to 2018， there were 5 055 deaths of gallbladder and biliary tract cancer in Tianjin City. The crude mortality increased from 0.94/105 to 4.41/105(t=14.23， P<0.001)， and the standardized mortality increased from 0.73/105 to 2.01/105(t=8.07， P<0.001). The median age of death had no significant change over the years(P>0.05)， and fluctuated around 70 years old. The mortality of gallbladder and biliary tract cancer before the age of 45 years was at a low level and had no significant change(P>0.05). The mortality began to increase after the age of 45 years(P<0.01) and had a significant increase at the age group of 65+. The standardized mortality of gallbladder and biliary tract cancer in male increased from 0.79/105 in 1999 to 2.21/105 in 2018(APC=4.19%， t=9.05， P<0.001)， and that in female increased from 0.68/105 in 1999 to 1.82/105 in 2018(APC=3.57%， t=5.89， P<0.001). The standardized mortality rate in urban areas increased from 1.05/105 in 1999 to 2.09/105 in 2018， and the standardized mortality rate in rural areas increased from 0.31/105 in 1999 to 1.87/105 in 2018(urban: APC=2.19%， t=3.78， P<0.001； rural: APC=8.06%， t=13.58， P<0.001). ［Conclusion］ The crude mortality rate and standardized rate of gallbladder and biliary tract cancer in Tianjin City increased significantly from 1999 to 2018. The elderly over 65 years old and urban residents are at higher risk of gallbladder and biliary tract cancer death， and there is no significant difference in gallbladder and biliary tract cancer death between men and women. Targeted prevention and treatment measures should be taken to reduce the death of gallbladder and biliary tract cancer. |
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