| 陆赛博,俞 浩,罗鹏飞,等.1990—2019年江苏省肝癌疾病负担变化分析[J].中国肿瘤,2022,31(6):450-456. |
| 1990—2019年江苏省肝癌疾病负担变化分析 |
| Trend of Disease Burden of Liver Cancer in Jiangsu Province from 1990 to 2019 |
| 投稿时间：2022-03-03 |
| DOI：10.11735/j.issn.1004-0242.2022.06.A004 |
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| 中文关键词: 肝癌 疾病负担 归因伤残调整寿命年率 江苏 |
| 英文关键词:liver cancer disease burden attributed disability adjusted life years rate Jiangsu |
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| 中文摘要: |
| 摘 要：［目的］ 分析江苏省1990—2019年肝癌疾病负担的变化趋势及其危险因素归因情况。［方法］ 根据2019年全球疾病负担（GBD）研究的江苏省数据，分析1990—2019年江苏省肝癌发病、死亡、伤残调整寿命年（DALY）水平，平均年度变化百分比（AAPC）用于描述年平均变化趋势，年度变化百分比（APC）用于描述不同阶段时间变化趋势，归因DALY率用于描述危险因素归因情况。［结果］ 1990—2019年江苏省肝癌整体发病率、死亡率、DALY率都呈下降趋势，分别下降4.66%、5.29%、5.20%（P＜0.001），但在2014年后发病率和DALY率重新出现缓慢上升的趋势（APC=1.17%、0.82%，P＜0.001）。伤残损失寿命年（YLD）占DALY的比例平均每年增加1.24%（P=0.001）；1990年和2019年吸烟都是江苏省肝癌归因DALY率的首位危险因素，2019年高体质指数跃升为第2位。［结论］ 江苏省肝癌疾病负担整体呈下降趋势，但近年来有上升趋势，仍需不断加强肝癌的防治工作，应重视吸烟与高体质指数对肝癌的危害。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the trend of disease burden of liver cancer and the attribution of risk factors in Jiangsu Province from 1990 to 2019. ［Methods］ Based on the 2019 Global Burden of Disease (GBD) study， we analyzed the incidence， mortality， disability-adjusted life years (DALY) of liver cancer in Jiangsu Province from 1990 to 2019. The average annual change percentage(AAPC) was used to analyze the annual average change trend， and the annual percentage change(APC) was applied to analyze the trend of time variation at different stages. The attributable DALY rate was calculated for its risk factors. ［Results］ The overall incidence， mortality and DALY rate of liver cancer in Jiangsu Province showed a decreasing trend from 1990 to 2019 with AAPC of 4.66%， 5.29% and 5.20%， respectively(P＜0.001)； however， the incidence and DALY rate increased again after 2014(APC=1.17%， 0.82%， P＜0.001). The proportion of years lived with disability(YLD) in DALY increased by 1.24% per year(P=0.001). Smoking was the first leading attributable risk factor for DALY rate of liver cancer in Jiangsu Province in 1990 and 2019， while high BMI ranked the second place in 2019. ［Conclusion］ The overall disease burden of liver cancer in Jiangsu Province shows a downward trend from 1990 to 2019， but there was an upward trend in recent years. It is necessary to continuously strengthen the prevention of liver cancer， and reduce the risk factors including smoking and high BMI. |
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