| 江雨琛,俞 浩,罗鹏飞.1990—2019年江苏省肺癌疾病负担及其危险因素变化趋势研究[J].中国肿瘤,2022,31(5):327-334. |
| 1990—2019年江苏省肺癌疾病负担及其危险因素变化趋势研究 |
| Trends of Burden on Lung Cancer and Related Risk Factors in Jiangsu Province from 1990 to 2019 |
| 投稿时间：2021-12-07 |
| DOI：10.11735/j.issn.1004-0242.2022.05.A002 |
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| 中文关键词: 肺癌 发病率 死亡率 疾病负担 伤残调整寿命年 危险因素 江苏 |
| 英文关键词:lung cancer incidence mortality disease burden disability-adjusted of life years risk factor Jiangsu |
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| 中文摘要: |
| 摘 要：［目的］ 分析1990—2019年江苏省肺癌疾病负担及其危险因素变化趋势。［方法］ 利用2019年全球疾病负担研究结果，分析1990—2019年江苏省居民肺癌的发病率、死亡率、伤残调整寿命年（DALY）、过早死亡率的变化趋势，运用人群归因危险百分比估计肺癌不同危险因素的归因水平。［结果］ 1990年和2019年江苏省居民肺癌的标化发病率分别是32.90/10万、42.02/10万，标化死亡率分别为33.69/10万、34.71/10万，过早死亡率分别为2.29%、1.86%，标化DALY率分别为1 084.91/10万、409.60/10万。30年间，男性、女性及合计标化发病率年均分别增加了0.71%（t为6.05~10.79，P均＜0.001）、1.04%（t为6.05~10.79，P均＜0.001）和0.83%（t为6.05~10.79，P均＜0.001），男性及全人群过早死亡率年均分别下降了1.02%（t=-7.04，P＜0.001）和0.68%（t=-6.52，P＜0.001），但男性、女性、男女合计标化死亡率（t=-0.55，P>0.05；t=1.93，P>0.05；t=1.01，P>0.05）及女性过早死亡率（t=-1.00，P>0.05）的变化均无统计学意义。标化过早死亡损失寿命年（YLL）率（t为-5.27~-4.99，P均＜0.001）、标化DALY率（t为-5.27~ -4.99，P＜0.001）均呈现下降趋势，标化伤残损失寿命年（YLD）率则呈现上升趋势（t=9.16，P均＜0.001），YLL在DALY中占比高达98.55%。在肺癌的归因顺位中，吸烟居首要原因，家庭空气污染由第2位下降至第8位，而大气颗粒物污染和二手烟的顺位上升。［结论］ 江苏省肺癌疾病负担总体呈下降趋势，但发病水平仍在上升，应将控烟及环境治理作为肺癌防控的重要手段，将中老年及男性人群作为重点关注人群，要关注肺癌疾病负担在女性中的增长趋势。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the trends of lung cancer disease burden and its risk factors in Jiangsu Province from 1990 to 2019. ［Methods］ Based on the results of the 2019 Global Burden of Disease Study(GBD2019)， the incidence， mortality， disability-adjusted life years(DALY) and premature mortality of lung cancer in Jiangsu Province from 1990 to 2019 were analyzed， and the attributing levels of different risk factors of lung cancer were estimated by population attributing risk percentage. ［Results］ The age-standardized incidence rates(ASIR) of lung cancer among residents of Jiangsu Province in 1990 and 2019 were 32.90/105 and 42.02/105， respectively； the age-standardized mortality rates(ASMR) of 33.69/105 and 34.71/105， respectively； the premature mortality rates of 2.29% and 1.86%， respectively； the age-standardized DALY rates of 1 084.91/105 and 409.60/105， respectively. Over the 30 years， the annual age-standardized incidence rates increased by 0.71%(t： 6.05～10.79， P<0.001)， 1.04%(t： 6.05～10.79， P<0.001) and 0.83%(t： 6.05～10.79， P<0.001) for men， women and the both， respectively， and the annual premature mortality rates decreased by 1.02%(t=-7.04， P<0.001) and 0.68%(t=-6.52， P<0.001) in men and the both， respectively， but no statistically significant changes were seen in the standardized mortality rate in men， women and both(t=-0.55， P>0.05； t=1.93， P>0.05； t=1.01， P>0.05) and in female premature mortality rate(t：-1.00， P>0.05). The rates of age-standardized years of life lost(YLL)(t： -5.27～-4.99， P<0.001) and age-standardized DALY(t=-5.27～-4.99， P<0.001) showed a decreasing trend， while the rate of age-standardized years lived with disability(YLD) showed an increasing trend(t=9.16， P<0.001)， and YLL accounted for 98.55% of DALY. Among the attributed causes of lung cancer， smoking ranked the first， while household air pollution decreased from the 2nd to the 8th in ranking， while atmospheric particulate matter pollution and secondhand smoke increased in ranking. ［Conclusion］ The overall burden of lung cancer in Jiangsu Province is on the decline， but the incidence level is still on the rise. Tobacco control and environmental management should be regarded as the important means of lung cancer prevention and control， middle-aged and elderly and male population should be regarded as the key population for prevention and control， and the increasing trend of lung cancer burden in female population should be paid attention to. |
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