| 汪韦宏,梁晨晨,张发明.肠道菌群重建在肿瘤治疗中的研究进展[J].中国肿瘤,2022,31(4):292-300. |
| 肠道菌群重建在肿瘤治疗中的研究进展 |
| Research Advances on Gut Microbiota Reconstruction in Cancer Therapy |
| 投稿时间：2022-01-15 |
| DOI：10.11735/j.issn.1004-0242.2022.04.A007 |
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| 中文关键词: 粪菌移植 洗涤菌群移植 肿瘤治疗 经内镜肠道植管术 |
| 英文关键词:fecal microbiota transplantation washed microbiota transplantation oncotherapy transendoscopic enteral tubing |
| 基金项目:南京医科大学樊代明整合医学研究基金 |
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| 中文摘要: |
| 摘 要：肠道菌群与人体相互作用机制及基于肠道菌群的诊疗研究已经成为全球热点。全文对重建肠道菌群在肿瘤及其并发症治疗中的作用进行综述，主要体现在针对化疗、放疗和免疫治疗的“增效减毒”。洗涤菌群移植是重建菌群的核心方式，不仅可以延缓肿瘤疾病进展、减少肿瘤治疗相关不良事件的发生以及改善肠道菌群组成，还能提高机体免疫，有望成为肿瘤治疗的一种新兴治疗手段。 |
| 英文摘要: |
| Abstract：Studies on the interaction between human microbiota and host， and its potential clinical application have become a global research hot topic. Animal studies have shown that reconstruction of gut microbiota used for treatment of cancer and its complication， can enhanced efficacy and reduce toxicity of chemotherapy， radiotherapy and immunotherapy. As the core of microbiota transplantation， washed microbiota transplantation can delay the progression of tumor， reduce the incidence of treatment-related adverse events and improve the composition of intestinal microorganisms， as well as enhance the body immunity. Reconstruction of gut microbiota is expected to become a novel modality for cancer therapy. |
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