| 姚 霜,庹吉妤,秦 宇.2012—2016年湖北省肿瘤登记地区结直肠癌发病、死亡状况及趋势分析[J].中国肿瘤,2022,31(2):119-126. |
| 2012—2016年湖北省肿瘤登记地区结直肠癌发病、死亡状况及趋势分析 |
| Analysis of the Incidence， Mortality and Trend of Colo-rectal Cancer in Hubei Cancer Registration Areas from 2012 to 2016 |
| 投稿时间：2021-08-23 |
| DOI：10.11735/j.issn.1004-0242.2022.02.A006 |
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| 中文关键词: 结直肠癌 发病率 死亡率 疾病负担 湖北 |
| 英文关键词:colorectal cancer incidence mortality disease burden Hubei |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 分析2012—2016年湖北省肿瘤登记地区结直肠癌的发病、死亡以及疾病负担情况。［方法］ 收集湖北省肿瘤登记地区2012—2016年结直肠癌发病、死亡资料，采用描述性流行病学方法，通过计算发病/死亡率、年龄别发病/死亡率、中国人口标化率（中标率）、世界人口标化率（世标率）等指标对结直肠癌的发病和死亡情况进行综合分析，同时根据世界卫生组织提供的公式计算伤残调整寿命年（disability-adjusted life years，DALY）和 DALY 率来估计结直肠癌的疾病负担；并利用 Joinpoint 回归模型计算年度变化百分比（annual percentage change，APC）及其95%置信区间（confidence interval，CI），分析结直肠癌发病率、死亡率的变化趋势。［结果］ 2012—2016年湖北省肿瘤登记地区结直肠癌新发病例15 912例，发病率为 26.02/10万，中标发病率为 16.80/10万，世标发病率为16.65/10万。80~84岁年龄组达到发病高峰，为149.84/10万。2012—2016年湖北省肿瘤登记地区结直肠癌死亡病例共计7 792例，粗死亡率为12.74/10万，中标死亡率为7.97/10万，世标死亡率为7.86/10万。死亡高峰出现在85+岁年龄组。2012—2016年结直肠癌发病率和死亡率总体趋势较稳定，APC分别为1.03%、2.00%。结直肠癌导致的DALY为129 193.73人年，DALY率为2.11/千人。其中结直肠癌DALY率在45岁之前较低，之后逐渐上升，在70~79岁年龄组达到峰值，而80岁之后略微下降。总体来看，男性结直肠癌的 DALY率高于女性。［结论］ 湖北省2012—2016年结直肠癌总体发病率和死亡率男性均高于女性，结直肠癌的DALY 率在70~79岁年龄组达到峰值，提示结直肠癌主要集中在老年人群。随着人口老龄化的加速，疾病负担将会越来越严重，湖北省应进一步加强癌症防控工作，男性以及高龄人群应作为结直肠癌防控的重点对象。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the incidence， mortality and disease burden of colorectal cancer in the cancer registration areas of Hubei Province from 2012 to 2016. ［Methods］ The data of the new cases and deaths of colorectal cancer from 2012 to 2016 in the cancer registration areas of Hubei Province were collected. The crude incidence/mortality rate， age-specific incidence/mortality rate， age-standardized rate by Chinese standard population in 2000(ASRC)， age-standardized rates by world standard(Segi’s) population(ASRW) were calculated. The disability-adjusted life years(DALY) and DALY rate were calculated to estimate the disease burden of colorectal cancer； and the Joinpoint regression model was used to calculate the annual percentage change(APC) to analyze the trend of the incidence and mortality of colorectal cancer. ［Results］ From 2012 to 2016， there were 15 912 new cases of colorectal cancer in the cancer registration areas of Hubei Province， with an incidence rate of 26.02/105. The age-standardized incidence rates by 2000’s Chinese standard population was 16.80/105， and the age-standardized incidence rates by world Segi’s population was 16.65/105. In the 80~84 age group， the incidence peaked at 149.84/105. From 2012 to 2016， there were 7 792 deaths from colorectal cancer in the cancer registration areas of Hubei Province， with a mortality rate of 12.74/105. The ASRC was 7.97/105， and the ASRW was 7.86/105. The peak of mortality occurred in the 85+ age group. The overall incidence and mortality of colorectal cancer were relatively stable， with APC of 1.03% and 2.00%， respectively. The DALY caused by colorectal cancer in 2012—2016 was 129 193.73 person-years， and the DALY rate was 2.11/1 000 persons. The DALY rate of colorectal cancer was low before the age of 45， and then gradually increased， reaching a peak in the 70~79 age group， and slightly decreased after the age of 80. Overall， the DALY rate of colorectal cancer in men was higher than that in women. ［Conclusion］ The overall incidence and mortality of colorectal cancer in Hubei Province from 2012 to 2016 are higher in men than those in women， and the DALY rate of colorectal cancer reaches its peak in the 70~79 age group， suggesting that colorectal cancer is mainly in the elderly. With the acceleration of population aging， the burden of disease will be increased. The colorectal cancer prevention and control should be further strengthened， men and the elderly should be the key targets. |
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