| 李卓颖,项永兵.肥胖与原发性肝癌关系的流行病学研究进展[J].中国肿瘤,2021,30(9):711-720. |
| 肥胖与原发性肝癌关系的流行病学研究进展 |
| Progress on Epidemiologic Studies for the Relationship Between Adiposity and Primary Liver Cancer |
| 中文关键词 修订日期：2021-05-19 |
| DOI：10.11735/j.issn.1004-0242.2021.09.A012 |
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| 中文关键词: 原发性肝癌 肥胖 脂肪分布 危险因素 流行病学研究 队列研究 |
| 英文关键词:primary liver cancer adiposity fat distribution risk factor epidemiologic study cohort study |
| 基金项目:国家重点研发计划项目（2016YFC1302503） |
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| 中文摘要: |
| 摘 要：原发性肝癌是常见的恶性肿瘤之一。近年来，肥胖与肝癌之间的关系逐渐受到公众和流行病学家的重视。该文对全身性肥胖、脂肪分布以及成年期体重改变与肝癌发病、预后关系的流行病学研究进行了综述。首先，介绍了传统的体质指数、腰围、腰臀比等指标以及成年早期肥胖和成年期体重改变与肝癌关系之间的研究进展；其次，针对一些较新的身体成分测量手段（如双能X线吸收法、计算机断层扫描、磁共振等）在肥胖与肝癌关系中的应用进行了简要描述；最后，由于肥胖和多种代谢紊乱关系密切，因此对2型糖尿病、代谢综合征、非酒精性脂肪肝病等与原发性肝癌之间的关系也进行了概述。 |
| 英文摘要: |
| bstract： Primary liver cancer is one of the most common malignancies. Recently， the association between adiposity and liver cancer has gradually attracted the attention of the public and epidemiologists. The current review systematically summarized the epidemiological studies on the relationship between general obesity， fat distribution and adult weight change with the incidence and prognosis of primary liver cancer. Firstly， the research progress on the relationship between traditional anthropometrics such as body mass index， waist circumference， waist-to-hip ratio， obesity in early adulthood and adult weight change with liver cancer were introduced. Secondly， the application of some new body composition measurement methods(such as dual-energy X-ray absorptiometry， computed tomography， magnetic resonance imaging， etc.) on the relationship between adiposity and liver cancer is briefly described. Finally， the association of type 2 diabetes mellitus， metabolic syndrome and non-alcoholic fatty liver disease with primary liver cancer is also briefly reviewed， as adiposity is closely associated with many metabolic disorders. |
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