| 胡志皇,常建华.PD-1/PD-L1抑制剂的剂量选择与优化[J].中国肿瘤,2021,30(5):385-392. |
| PD-1/PD-L1抑制剂的剂量选择与优化 |
| Dose Selection and Optimization of PD-1/PD-L1 Inhibitors |
| 中文关键词 修订日期：2020-11-13 |
| DOI：10.11735/j.issn.1004-0242.2021.05.A011 |
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| 中文关键词: 免疫治疗 PD-1/PD-L1 药效学 药代动力学 剂量选择 |
| 英文关键词:immunotherapy PD-1/PD-L1 pharmacodynamics pharmacokinetics dose selection |
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| 中文摘要: |
| 摘 要：肿瘤免疫治疗中，以程序性死亡受体1（programmed cell death protein 1，PD-1）/程序性死亡受体—配体1（programmed cell death-ligand 1，PD-L1）抑制剂为代表的免疫检查点单抗阻断治疗已逐渐成为肿瘤治疗领域的焦点。合理用药是使患者达到有效临床获益的重要环节，其中用药剂量准确是合理用药的关键。因此，充分了解PD-1/PD-L1抑制剂的药代动力学、药效学特点以及由此衍生的剂量选择和剂量优化方案对消除用药疑虑、增强用药依从性，从而实现规范化用药具有重要的临床意义。全文就PD-1/PD-L1抑制剂的剂量优化历程和临床应用进行综述，以期为PD-1/PD-L1抑制剂的临床规范使用提供参考。 |
| 英文摘要: |
| Abstract：Immune checkpoint inhibitors of the programmed cell death protein 1(PD-1) and programmed cell death-ligand 1(PD-L1) have become the mainstay of cancer immunotherapy. The rational use of medicine，especially the selection of optimal dose is important for patients to achieve effective clinical benefits. Therefore，understanding the pharmacokinetics and pharmacodynamics of PD-1/PD-L1 inhibitors to select and optimize the drug dose is the key issue for eliminating doubts about medication，enhancing medication compliance，and achieving standardized use of PD-1/PD-L1 inhibitors. In this article，the dose selection and clinical application of PD-1/PD-L1 inhibitors are reviewed to provide reference for the clinical use of PD-1/PD-L1 inhibitors. |
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