| 李 军,顾建华,何 永.2006—2015年四川省盐亭县上消化道癌发病与内镜筛查结果对比分析[J].中国肿瘤,2021,30(5):346-351. |
| 2006—2015年四川省盐亭县上消化道癌发病与内镜筛查结果对比分析 |
| Incidence of Upper Gastrointestinal Cancer and Endoscopy Screening Results in Yanting County，Sichuan Province |
| 中文关键词 修订日期：2020-07-27 |
| DOI：10.11735/j.issn.1004-0242.2021.05.A005 |
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| 中文关键词: 内镜筛查 食管癌 胃癌 肿瘤登记 四川 |
| 英文关键词:endoscopy screening esophageal cancer gastric cancer cancer registration Sichuan |
| 基金项目:国家重点研发计划（2016YFC0901400，2016YFC1302800，2018YFC2000705） |
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| 中文摘要: |
| 摘 要：［目的］ 对比分析我国食管癌高发区四川省盐亭县2006—2015年间，上消化道癌发病情况及高危人群上消化道癌内镜检出情况，为下一步明确人群防治工作的重点提供理论依据。［方法］ 将盐亭县40～69岁设为内镜筛查目标人群，对其采用内镜下碘染色及指示性活检进行筛查，统计分析目标人群早期食管癌、贲门癌、远端胃癌及相应癌前病变的检出情况；依托肿瘤登记数据，分析2006—2015年间盐亭县远端胃癌、贲门癌及食管癌发病情况。［结果］ 2006—2015年盐亭县肿瘤登记结果显示，十年期间，盐亭县40～69岁人群中胃癌发病率最高，约为食管癌的1.13倍（445.13/10万vs 393.4/10万），其中远端胃癌发病率约占总胃癌发病率的3/4；内镜筛查42 340人，盐亭县40～69岁人群早期食管癌及癌前病变检出率显著高于早期胃部病变检出率（0.66% vs 0.28%），其中远端胃部早期癌及癌前病变检出率略高于贲门部（0.15% vs 0.13%）；对6048例贲门黏膜无异常者进行高发位点的常规性活检，发现13例早期贲门癌癌变患者，检出率为0.21%，高于指示活检的0.12%。［结论］ 盐亭县胃癌发病率高于食管癌，远端胃癌是盐亭县胃癌主要类型，且发病率高，检出率低，下一步工作重心应放在提高早期胃癌及癌前病变的筛查及诊断水平上。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence of upper gastrointestinal cancers in Yanting County during 2006—2015 and the results of upper gastrointestinal cancer screening in high-risk areas. ［Methods］According to the requirements of the screening protocol，local residents aged 40～69 were enrolled in the screening program. The early detection rates，incidence trend and proportion of esophageal cancer，distal gastric cancer and gastric cardia cancer were analyzed based on the upper gastrointestinal cancer screening program and cancer registration system，respectively. ［Results］ The cancer data of 2006—2015 obtained from cancer registration system showed that the incidence of gastric cancer was 1.13 times higher than esophageal cancer(445.13/105 vs 393.4/105). The incidence of distal gastric cancer accounted for about 3/4 of the total incidence of gastric cancer. A total of 42 340 local residents participated in endoscopic screening program，the detection rate of early esophageal cancer and precancerous lesions was higher than that of early gastric cardia lesions(0.66% vs 0.28%)；the detection rate of early distal gastric cancer，precancerous lesions and those of cardia were 0.15% and 0.13%，respectively. Routine biopsies of 6048 patients with normal cardia mucosa were performed at high incidence sites，and 13 cases of early-stage cardia cancer were found with the detection rate 0.21%，which was higher than that of indicative biopsy(0.12%). ［Conclusion］The incidence of gastric cancer is higher than that of esophageal cancer，and distal gastric cancer is the main type in Yanting County，however it has high incidence and low detection rate. Necessary measures should be taken to raise the endoscopic examination compliance and improve the diagnostic rate of early gastric cancer for the target population. |
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