| 杨晓冉,杨 欢,闫慧姣.2001—2010年中国胃肠胰神经内分泌癌临床流行病学研究[J].中国肿瘤,2021,30(1):74-80. |
| 2001—2010年中国胃肠胰神经内分泌癌临床流行病学研究 |
| Clinical Epidemiological Study of Gastroenteropancreatic Neuroendocrine Carcinoma in China，2001—2010 |
| 中文关键词 修订日期：2020-08-19 |
| DOI：10.11735/j.issn.1004-0242.2021.01.A009 |
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| 中文关键词: 神经内分泌癌 回顾性研究 多中心 临床流行病学 消化系统肿瘤 |
| 英文关键词:gastroenteropancreatic neuroendocrine carcinoma retrospective analysis multi-center clinical epidemiology digestive system tumor |
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| 中文摘要: |
| 摘 要：［目的］探讨中国胃肠胰神经内分泌癌(gastroenteropancreatic neuroendocrine carcinoma，GEP-NEC)的临床流行病学特征。［方法］本研究是一项基于医院的全国多中心10年（2001—2010年）回顾性临床流行病学调查研究。根据2010年WHO消化道肿瘤分类标准重新归类病案资料，纳入病理诊断为GEP-NEC和胃肠胰神经内分泌瘤(gastroenteropancreatic neuroendocrine tumor，GEP-NET)的患者，采用病例报告表，收集患者人口统计学信息、潜在危险因素、临床诊疗特点，研究GEP-NEC与GEP-NET临床表现、影像学检查、临床病理结果、治疗方式等的差异。［结果］ 共479例确诊为GEP-NEC，其高发部位为胃（66.6%，319/479）、直肠（11.3%，54/479）、胰腺（8.4%，40/479）。相较GEP-NET，GEP-NEC在老年、男性、有吸烟史人群中更常见（P<0.001）。GEP-NEC病例数呈现持续增加趋势，与GEP-NET相比，具有脉管内瘤栓、神经侵犯、坏死等恶性特征的患者比例更大（P<0.05），诊断时发生局部浸润或远处转移的患者比例更大（P<0.001），仅24.2%患者局限于原发部位。88.1%（422/479）的GEP-NEC患者接受了开放式手术，接受化疗的患者构成比高于GEP-NET（P<0.001）。［结论］ 中国GEP-NEC病例数呈现持续增加趋势，诊断时多处于局部浸润或远处转移。对这一类少见且高度异质性的肿瘤，需要更多临床流行病学研究，为临床早诊早治提供依据。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate clinical epidemiological feature of gastroenteropancreatic neuroendocrine carcinoma(GEP-NEC) in China. ［Methods］ This was a hospital-based，nation-wide，and multi-center 10-year(2001—2010) retrospective study.The medical records were reclassified according to the 2010 WHO classification of gastrointestinal tumors，and patients pathologically diagnosed as GEP-NEC and patients with gastroenteropancreatic neuroendocrine tumors(GEP-NET) were included in the analysis.The data of demographic information，potential risk factors，features of clinical diagnosis and treatment were collected；and the differences in clinical characteristics，imaging findings，pathological results and treatment methods were compared between patients with GEP-NEC and GEP-NET. ［Results］ There were 479 cases of GEP-NEC，and the stomach was most involved organ(66.6%，319/479)，followed by rectum(11.3%，54/479) and pancreas(8.4%，40/479). Compared with GEP-NET，GEP-NEC was more prevalent in the elderly，male，and those with a history of smoking(P<0.001). The case number of GEP-NEC showed continued increase. Compared with GEP-NET patients，there was a higher proportion of GEP-NEC patients with malignant features such as intravascular thrombosis，nerve infiltration，necrosis(P<0.05)，and a greater proportion of GEP-NEC with local infiltration or distant metastasis at diagnosis(P<0.001)，only 24.2% of GEP-NEC were confined to the primary site. 88.1% of GEP-NEC received open surgery，and the proportion of patients receiving chemotherapy was higher than that of NET(P<0.001). ［Conclusion］The number of GEP-NEC cases in China has been increasing and the majority were local invasion or metastatic at diagnosis. For rare and highly heterogeneous tumors like GEP-NEC，more clinical epidemiological studies are needed to provide evidence for early diagnosis and treatment. |
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