| 高一丁,应杰儿.分泌模块化钙结合蛋白?鄄2在肿瘤中的研究进展[J].中国肿瘤,2021,30(1):67-73. |
| 分泌模块化钙结合蛋白?鄄2在肿瘤中的研究进展 |
| Research Progress on Secreted Modular Calcium Binding Protein?鄄2 in Tumor |
| 中文关键词 修订日期：2020-10-15 |
| DOI：10.11735/j.issn.1004-0242.2021.01.A008 |
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| 中文关键词: 分泌模块化钙结合蛋白-2 基质 肿瘤 |
| 英文关键词:secreted modular calcium binding protein-2 matrix tumor |
| 基金项目:浙江省中医药科技计划项目（2021ZZ005） |
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| 中文摘要: |
| 摘 要：细胞微环境包括细胞外基质、免疫细胞和基质细胞等，肿瘤在其发生、发展过程中受到肿瘤细胞微环境的调控。分泌模块化钙结合蛋白-2（secreted modular calcium binding protein-2，SMOC-2蛋白）是新近发现的基质细胞蛋白，在正常人体组织及多种肿瘤组织内均有表达。SMOC-2蛋白参与调控肿瘤细胞周期进程、血管生成、细胞增殖、细胞附着和迁移，并在原发性肝细胞肝癌、结直肠癌、子宫内膜癌、肺癌等不同肿瘤中表现出不同作用。该文对SMOC-2蛋白的生物学功能及其与原发性肝细胞肝癌、结直肠癌、子宫内膜癌、肺癌等肿瘤的关系进行综述。 |
| 英文摘要: |
| Abstract：The development of tumor is regulated by the cellular microenvironment，including extracellular matrix，immune cells and stromal cells. Secreted modular calcium binding protein-2(SMOC-2 protein) is a newly discovered stromal cell protein，which is expressed in normal human tissues and various tumor tissues. SMOC-2 protein is involved in the regulation of tumor cell cycle progression，angiogenesis，cell proliferation，cell attachment and migration，and has different roles in primary hepatocellular carcinoma，colorectal cancer，endometrial cancer，lung cancer and other tumors. This article reviews the biological function of SMOC-2 protein and its relationship with primary hepatocellular carcinoma，colorectal cancer，endometrial cancer，lung cancer. |
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