| 中文关键词: 间歇性低氧 肺癌 肿瘤微环境 |
| 英文关键词:intermittent hypoxia lung cancer tumor microenvironment |
| 基金项目:河北省自然科学基金（H2018423041，H2019423136） |
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| 中文摘要: |
| 摘 要：肿瘤生长过程中的微循环异常可导致肿瘤内部反复缺氧引起间歇性低氧（intermittent hypoxia， IH），特别是在生长迅速的肿瘤中常见。肿瘤发生的间歇性低氧周期可持续几分钟至数天，与肿瘤的进展、侵袭、转移和治疗中的耐药性有关。在过去的十年中，越来越多的研究探讨了间歇性低氧对肺癌的影响，提示间歇性低氧可增强肺癌细胞的增殖能力及对放疗的耐受性。这可能与间歇性低氧诱导的氧化应激和炎症反应有关。该文综述了间歇性低氧与肺癌的关系及影响肺癌的可能机制，总结了针对间歇性低氧的肺癌治疗措施。 |
| 英文摘要: |
| Abstract：Intermittent hypoxia(IH) is related to the aberrant circulation observed in cancer patients，particularly in those with rapidly growing tumors. IH in tumor occurs with periodicity from minutes to days，is associated with accelerated tumor progression，invasion，metastasis and resistance to therapies. An increasing number of studies have examined the effect of IH on lung cancer behavior over the last decade，indicating that lung cancer cell lines with IH treatment were more proliferative and presented higher resistance to radiotherapy. The phenomenon may be explained by oxidative stress and inflammation after exposure to IH. This article reviews the relationship between IH and lung cancer and the possible mechanism of IH in cancer progression；the treatment targeting IH in lung cancer is also summarized. |
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