| 中文关键词: 胶质瘤 外泌体 肿瘤微环境 生物标志物 免疫治疗 |
| 英文关键词:glioma exosomes tumor microenvironment biomarker immunotherapy |
| 基金项目:重庆医科大学院内孵化重点项目（KY19026） |
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| 中文摘要: |
| 摘 要：胶质瘤是常见的原发性脑肿瘤，具有高侵袭性、高复发性、高致死率的特点。外泌体是由细胞分泌的功能性囊泡结构，普遍存在于生物体液中，其具有广泛的内容物，并参与了多种生理和病理过程，尤其是肿瘤的发生发展。外泌体可诱导受体细胞产生大量的生物学过程，与肿瘤的形成、发展、转移、浸润和耐药性等密切相关。外泌体在胶质瘤的诊断及治疗中的作用也日益受到重视，胶质瘤外泌体的特异性成分可作为诊断和预测生物标志物，外泌体也可作为运送抗癌药物的载体，经修饰的外泌体可以用于胶质瘤的免疫治疗。本文综述了外泌体在胶质瘤进展中的重要作用及其对诊断和新治疗策略发展的意义。 |
| 英文摘要: |
| Abstract：Glioma is a common primary brain tumor with high invasiveness，high recurrence and high fatality rate. Exosomes are functional vesicle structures secreted by cells and are ubiquitous in biological fluids. They have a wide range of contents and participate in a variety of physiological and pathological processes，especially the occurrence and development of tumors. Exosomes can induce a large number of biological processes in recipient cells，which are closely related to tumor formation，development，metastasis，infiltration and drug resistance. The role of exosomes in the diagnosis and treatment of gliomas has also received increasing attention. The specific components of glioma exosomes can be used as diagnostic and predictive biomarkers，and exosomes can also be used as carriers for the delivery of anticancer drugs，Modified exosomes can be used for glioma immunotherapy. This article reviews the important role of exosomes in the progression of glioma and its significance for the development of diagnosis and new treatment strategies. |
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