| 郭鱼波,樊英怡,裴晓华.甲状旁腺激素相关蛋白调控乳腺发育和乳腺癌骨转移的研究进展[J].中国肿瘤,2020,29(9):701-707. |
| 甲状旁腺激素相关蛋白调控乳腺发育和乳腺癌骨转移的研究进展 |
| Research Progress of Parathyroid Hormone?鄄related Protein in Regulating Breast Development and Bone Metastasis of Breast Cancer |
| 中文关键词 修订日期：2020-01-06 |
| DOI：10.11735/j.issn.1004-0242.2020.09.A011 |
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| 中文关键词: 甲状旁腺激素相关蛋白 乳腺发育 乳腺癌 骨转移 中医药 |
| 英文关键词:parathyroid hormone-related protein(PTHrP) mammary gland development breast cancer bone metastasis traditional Chinese medicine |
| 基金项目:国家自然科学基金面上项目（81774319）；国家自然科学基金地区科学基金项目（81560775）；北京市自然科学基金面上项目（7182098）；国家留学基金资助 |
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| 中文摘要: |
| 摘 要：甲状旁腺激素相关蛋白(parathyroid hormone-related protein，PTHrP)，又称甲状旁腺激素类似激素(parathyroid hormone-like hormone，PTHLH)，表达于乳腺肌上皮细胞和管腔上皮细胞，是乳腺发育和生物学行为所必需的。该文综述了PTHrP对乳腺发育的影响，PTHrP在早期乳腺癌和乳腺癌骨转移中的不同作用，以及中医药对PTHrP的调控，可为临床治疗乳腺癌骨转移提供新思路。 |
| 英文摘要: |
| Abstract：Parathyroid hormone-related protein(PTHrP)，also known as parathyroid hormone like hormone(PTHLH)，is expressed in mammary basal/myoepithelial cells and luminal cells，which is necessary for normal mammary gland development and biology function. This artical reviews the impact of PTHrP on mammary development，the different effects on early breast cancer and bone metastasis of breast cancer. The article also summaries the regulation of traditional Chinese medicine on PTHrP，which may provide insight for clinical treatment of bone metastasis of breast cancer. |
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