| 于军辉,金 岚,王 今.循环肿瘤细胞对Ⅱ期结直肠癌根治术预后的预测价值73例分析[J].中国肿瘤,2020,29(3):230-234. |
| 循环肿瘤细胞对Ⅱ期结直肠癌根治术预后的预测价值73例分析 |
| Prognostic Value of Circulating Tumor Cells in Stage Ⅱ Colorectal Cancer Undergoing Curative Resection：Seventy-three Cases Report |
| 中文关键词 修订日期：2019-11-10 |
| DOI：10.11735/j.issn.1004-0242.2020.03.A012 |
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| 中文关键词: 循环肿瘤细胞 结直肠癌 辅助化疗 预后因素 |
| 英文关键词:circulating tumor cell colorectal cancer adjuvant chemotherapy prognostic factor |
| 基金项目:国家科技支撑计划资助项目国家科技支撑计划课题（2015BAI13B09）；北京市医管局临床医学发展专项经费资助项目（ZYLX201504）；北京市卫生系统高层次卫生技术人才培养计划（2015-3-005） |
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| 中文摘要: |
| 摘 要：［目的］阐明循环肿瘤细胞（CTC）在Ⅱ期结直肠癌（CRC）患者根治术预后的预测作用。［方法］ 采集73例Ⅱ期CRC患者静脉血，应用阴离子富集和免疫荧光原位杂交法（imFISH）鉴定CTC。并对73例患者的临床病理特征和无复发生存期（RFS）进行分析。［结果］ Ⅱ期CRC患者的CTC总阳性率为65.8%。无复发与复发患者CTC阳性率分别为62.7％和87.5％。平均RFS为42.6个月，CTC阳性者vs CTC阴性者平均RFS分别为40.7个月vs 46.0个月（P=0.043）。CTC阳性并且行辅助化疗患者未出现复发，而CTC阳性未行辅助化疗患者平均RFS为45.8个月。［结论］ CTC可用作预测Ⅱ期CRC患者平均RFS的预后因素，并有可能筛选出可以进行辅助化疗的Ⅱ期CRC患者。 |
| 英文摘要: |
| Abstract：［Purpose］To clarify the role of circulating tumor cell(CTC) in stage Ⅱ colorectal cancer(CRC) patients treated with curative surgery. ［Methods］ CTCs were detected using a negative enrichment and immuno-fluorescence in situ hybridization (imFISH) staining method from the venous blood samples obtained from 73 stage Ⅱ CRC patients. The clinic-pathologic characteristics and recurrence free survival(RFS) were collected. ［Results］73 stage Ⅱ CRC patients were included in this study. The CTC positive rate was 65.8% in all patients，62.7% in no recurrence patients and 87.5% in recurrent patients. The average RFS was 42.6 months for all patients，40.7 months for CTC-positive patients，and 46.0 months for CTC-negative patients(P=0.043). No recurrence occurred for CTC-positive patients treated with adjuvant chemotherapy. The average RFS for CTC-positive patients without adjuvant chemotherapy was 45.8 months. ［Conclusion］ CTC could be used as a prognostic factor to predict average RFS for stage Ⅱ CRC patients，and may have potential in selecting stage Ⅱ CRC patients for adjuvant chemotherapy. |
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